Transfusion-Transmitted Infections: an Update on Product Screening, Diagnostic Techniques, and the Path Ahead

The mandated testing of blood components for infectious diseases, to prevent transfusion-transmitted infections (TTIs), began in the 1950s. Since then, changes in predonation questionnaires and advances in testing techniques have afforded more sensitive and specific tests for pathogens, in addition...

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Veröffentlicht in:	Journal of clinical microbiology 2018-07, Vol.56 (7)
Hauptverfasser:	Dean, Christina L, Wade, Jenna, Roback, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood - microbiology Blood - parasitology Blood - virology Blood Donors Blood Transfusion - standards Blood Transfusion - trends Clinical Laboratory Techniques - trends Communicable Diseases - blood Communicable Diseases - diagnosis Humans Mass Screening - trends Minireview Patient Safety Transfusion Reaction - prevention & control
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container_title	Journal of clinical microbiology
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creator	Dean, Christina L Wade, Jenna Roback, John D
description	The mandated testing of blood components for infectious diseases, to prevent transfusion-transmitted infections (TTIs), began in the 1950s. Since then, changes in predonation questionnaires and advances in testing techniques have afforded more sensitive and specific tests for pathogens, in addition to allowing earlier detection. Given that these approaches have very low but detectable failure rates, the recent development and implementation of proactive pathogen reduction approaches is the new forefront of TTI prevention strategies. With globalization and the ability of pathogens to evolve rapidly, continuous redefining of testing standards and laboratory techniques is paramount for maintaining a safe blood supply.
doi_str_mv	10.1128/JCM.00352-18
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source	American Society for Microbiology; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects	Blood - microbiology Blood - parasitology Blood - virology Blood Donors Blood Transfusion - standards Blood Transfusion - trends Clinical Laboratory Techniques - trends Communicable Diseases - blood Communicable Diseases - diagnosis Humans Mass Screening - trends Minireview Patient Safety Transfusion Reaction - prevention & control
title	Transfusion-Transmitted Infections: an Update on Product Screening, Diagnostic Techniques, and the Path Ahead
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