Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease
Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship wit...
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| Veröffentlicht in: | Journal of clinical and translational hepatology 2018-06, Vol.6 (2), p.135-140 |
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| container_title | Journal of clinical and translational hepatology |
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| creator | Jamil, Zubia Arif, Sharmin Khan, Anum Durrani, Asghar Aurangzeb Yaqoob, Nayyar |
| description | Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients.
Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.
Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (
>0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5, |
| doi_str_mv | 10.14218/JCTH.2017.00055 |
| format | Article |
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Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.
Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (
>0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5,
<0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (
<0.05).
Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.</description><identifier>ISSN: 2225-0719</identifier><identifier>EISSN: 2310-8819</identifier><identifier>DOI: 10.14218/JCTH.2017.00055</identifier><identifier>PMID: 29951357</identifier><language>eng</language><publisher>China: Department of Medicine, Foundation University Medical College, Islamabad, Pakistan%Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan</publisher><subject>Original</subject><ispartof>Journal of clinical and translational hepatology, 2018-06, Vol.6 (2), p.135-140</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2018 Authors. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-b91f4e72077f07106f002fef6fc9932f9aaaaafff27eefb1440b237ebf6068f43</citedby><cites>FETCH-LOGICAL-c433t-b91f4e72077f07106f002fef6fc9932f9aaaaafff27eefb1440b237ebf6068f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/lcyzhgbzz-e/lcyzhgbzz-e.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018313/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018313/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29951357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jamil, Zubia</creatorcontrib><creatorcontrib>Arif, Sharmin</creatorcontrib><creatorcontrib>Khan, Anum</creatorcontrib><creatorcontrib>Durrani, Asghar Aurangzeb</creatorcontrib><creatorcontrib>Yaqoob, Nayyar</creatorcontrib><title>Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease</title><title>Journal of clinical and translational hepatology</title><addtitle>J Clin Transl Hepatol</addtitle><description>Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients.
Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.
Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (
>0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5,
<0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (
<0.05).
Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.</description><subject>Original</subject><issn>2225-0719</issn><issn>2310-8819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkc1vGyEUxFHVqonS3HOqOPbQdR-wX1wqVXbapLLUKEpyRSx-eInWrAu7iey_vmzsRi0XnsRvhoEh5ILBjOWc1V9-zu-uZhxYNQOAonhDTrlgkNU1k2_TzHmRQcXkCTmP8TEhrGBQSnhPTriUBRNFdUrsgxv0xnm6oAu0zjj0Zke1X9HrIdJb7PTgeh9bt6XPbmjpvHXdKrsZ12nsdIw0SW8Sgz7hRyL03hm6dE8Y6MJF1BE_kHdWdxHPj_sZuf9-eTe_ypa_flzPvy0zkwsxZI1kNseKQ1XZFB1KC8At2tIaKQW3Uk_LWssrRNuwPIeGiwobW0JZ21ycka8H3-3YbHBlUqygO7UNbqPDTvXaqf9PvGvVun9SJbBaMJEMPh8MnrW32q_VYz8GnyKrzuz27brZ7xWmP6-BA0z4p-N9of89YhzUxkWDXac99mNUHEqWQ_KdUDigJvQxBrSvqRiol0LVVKiaClUvhSbJx39f8yr4W5_4A-pSnNo</recordid><startdate>20180628</startdate><enddate>20180628</enddate><creator>Jamil, Zubia</creator><creator>Arif, Sharmin</creator><creator>Khan, Anum</creator><creator>Durrani, Asghar Aurangzeb</creator><creator>Yaqoob, Nayyar</creator><general>Department of Medicine, Foundation University Medical College, Islamabad, Pakistan%Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan</general><general>XIA & HE Publishing Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20180628</creationdate><title>Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease</title><author>Jamil, Zubia ; Arif, Sharmin ; Khan, Anum ; Durrani, Asghar Aurangzeb ; Yaqoob, Nayyar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-b91f4e72077f07106f002fef6fc9932f9aaaaafff27eefb1440b237ebf6068f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Jamil, Zubia</creatorcontrib><creatorcontrib>Arif, Sharmin</creatorcontrib><creatorcontrib>Khan, Anum</creatorcontrib><creatorcontrib>Durrani, Asghar Aurangzeb</creatorcontrib><creatorcontrib>Yaqoob, Nayyar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical and translational hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamil, Zubia</au><au>Arif, Sharmin</au><au>Khan, Anum</au><au>Durrani, Asghar Aurangzeb</au><au>Yaqoob, Nayyar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease</atitle><jtitle>Journal of clinical and translational hepatology</jtitle><addtitle>J Clin Transl Hepatol</addtitle><date>2018-06-28</date><risdate>2018</risdate><volume>6</volume><issue>2</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>2225-0719</issn><eissn>2310-8819</eissn><abstract>Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients.
Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.
Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (
>0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5,
<0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (
<0.05).
Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.</abstract><cop>China</cop><pub>Department of Medicine, Foundation University Medical College, Islamabad, Pakistan%Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan</pub><pmid>29951357</pmid><doi>10.14218/JCTH.2017.00055</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Original |
| title | Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease |
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