The Role of Catechins in Cellular Responses to Oxidative Stress
Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2018-04, Vol.23 (4), p.965 |
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| creator | Bernatoniene, Jurga Kopustinskiene, Dalia Marija |
| description | Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases. |
| doi_str_mv | 10.3390/molecules23040965 |
| format | Article |
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Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules23040965</identifier><identifier>PMID: 29677167</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aging ; Animals ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Cancer ; Cardiovascular diseases ; Catechin ; Catechin - chemistry ; Catechin - pharmacology ; Chelating agents ; Cocoa ; Detoxification ; Diabetes mellitus ; Disease Susceptibility ; Enzymes ; Flavanols ; Green tea ; Humans ; Metal ions ; Mitochondria - drug effects ; Mitochondria - metabolism ; Molecular Structure ; Oxidants ; Oxidation ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidizing agents ; Polyphenols ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Review ; Tea ; Wine</subject><ispartof>Molecules (Basel, Switzerland), 2018-04, Vol.23 (4), p.965</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-efd6345749b79f36bdf0538ca9077e6f06e6eca54ce7d093b6a47056f6d605f03</citedby><cites>FETCH-LOGICAL-c493t-efd6345749b79f36bdf0538ca9077e6f06e6eca54ce7d093b6a47056f6d605f03</cites><orcidid>0000-0003-1744-2932</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29677167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernatoniene, Jurga</creatorcontrib><creatorcontrib>Kopustinskiene, Dalia Marija</creatorcontrib><title>The Role of Catechins in Cellular Responses to Oxidative Stress</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases.</description><subject>Aging</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>Catechin</subject><subject>Catechin - chemistry</subject><subject>Catechin - pharmacology</subject><subject>Chelating agents</subject><subject>Cocoa</subject><subject>Detoxification</subject><subject>Diabetes mellitus</subject><subject>Disease Susceptibility</subject><subject>Enzymes</subject><subject>Flavanols</subject><subject>Green tea</subject><subject>Humans</subject><subject>Metal ions</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Molecular Structure</subject><subject>Oxidants</subject><subject>Oxidation</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>Polyphenols</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Review</subject><subject>Tea</subject><subject>Wine</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNplkUtLAzEUhYMo1tcPcCMBN26qd5JM0mwUKb5AEHysQ5q5sVOmk5rMiP57I9biY5WE-53DPTmE7BdwzLmGk3lo0PUNJsZBgJblGtkqBINhfur1H_cB2U5pBsAKUZSbZMC0VKqQaoucPU6R3mcfGjwd2w7dtG4TrVs6xqbpGxvpPaZFaBMm2gV691ZXtqtfkT50EVPaJRveNgn3lucOebq8eBxfD2_vrm7G57dDJzTvhugryUWphJ4o7bmcVB5KPnJWg1IoPUiU6GwpHKoKNJ9IKxSU0stKQumB75DTL99FP5lj5bDtom3MItZzG99NsLX5PWnrqXkOr0ZCoZhW2eBoaRDDS4-pM_M6uZzRthj6ZBiwkS7zr36ih3_QWehjm-NlSsBopDljmSq-KBdDShH9apkCzGc95l89WXPwM8VK8d0H_wCKzo15</recordid><startdate>20180420</startdate><enddate>20180420</enddate><creator>Bernatoniene, Jurga</creator><creator>Kopustinskiene, Dalia Marija</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1744-2932</orcidid></search><sort><creationdate>20180420</creationdate><title>The Role of Catechins in Cellular Responses to Oxidative Stress</title><author>Bernatoniene, Jurga ; Kopustinskiene, Dalia Marija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-efd6345749b79f36bdf0538ca9077e6f06e6eca54ce7d093b6a47056f6d605f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Cancer</topic><topic>Cardiovascular diseases</topic><topic>Catechin</topic><topic>Catechin - chemistry</topic><topic>Catechin - pharmacology</topic><topic>Chelating agents</topic><topic>Cocoa</topic><topic>Detoxification</topic><topic>Diabetes mellitus</topic><topic>Disease Susceptibility</topic><topic>Enzymes</topic><topic>Flavanols</topic><topic>Green tea</topic><topic>Humans</topic><topic>Metal ions</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Molecular Structure</topic><topic>Oxidants</topic><topic>Oxidation</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidizing agents</topic><topic>Polyphenols</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Review</topic><topic>Tea</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernatoniene, Jurga</creatorcontrib><creatorcontrib>Kopustinskiene, Dalia Marija</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernatoniene, Jurga</au><au>Kopustinskiene, Dalia Marija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Catechins in Cellular Responses to Oxidative Stress</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2018-04-20</date><risdate>2018</risdate><volume>23</volume><issue>4</issue><spage>965</spage><pages>965-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. 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| subjects | Aging Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Cancer Cardiovascular diseases Catechin Catechin - chemistry Catechin - pharmacology Chelating agents Cocoa Detoxification Diabetes mellitus Disease Susceptibility Enzymes Flavanols Green tea Humans Metal ions Mitochondria - drug effects Mitochondria - metabolism Molecular Structure Oxidants Oxidation Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Oxidizing agents Polyphenols Reactive oxygen species Reactive Oxygen Species - metabolism Review Tea Wine |
| title | The Role of Catechins in Cellular Responses to Oxidative Stress |
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