Orotidine 5′-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis

Conspectus The mystery associated with catalysis by what were once regarded as protein black boxes, diminished with the X-ray crystallographic determination of the three-dimensional structures of enzyme–substrate complexes. The report that several high-resolution X-ray crystal structures of orotidin...

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Veröffentlicht in:	Accounts of chemical research 2018-04, Vol.51 (4), p.960-969
Hauptverfasser:	Richard, John P, Amyes, Tina L, Reyes, Archie C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Carbon Dioxide - chemistry Carbon Dioxide - metabolism Crystallography, X-Ray Hydrophobic and Hydrophilic Interactions Models, Molecular Orotidine-5'-Phosphate Decarboxylase - analysis Orotidine-5'-Phosphate Decarboxylase - metabolism
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