Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress

The human malaria parasite Plasmodium falciparum proliferates in red blood cells following repeated cycles of invasion, multiplication, and egress. P. falciparum serine repeat antigen 5 (PfSERA5), a putative serine protease, plays an important role in merozoite egress. However, regulation of its act...

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Veröffentlicht in:	The Journal of biological chemistry 2018-06, Vol.293 (25), p.9736-9746
Hauptverfasser:	Iyer, Gayatri R., Singh, Shailja, Kaur, Inderjeet, Agarwal, Shalini, Siddiqui, Mansoor A., Bansal, Abhisheka, Kumar, Gautam, Saini, Ekta, Paul, Gourab, Mohmmed, Asif, Chitnis, Chetan E., Malhotra, Pawan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - metabolism Calcium - metabolism CDPK1 Erythrocytes - parasitology Erythrocytes - pathology Humans malaria Malaria, Falciparum - parasitology Merozoites - physiology merozoites egress Molecular Bases of Disease phosphoproteomics Phosphorylation plasmodium Plasmodium falciparum Plasmodium falciparum - pathogenicity posttranslational modification (PTM) protein phosphorylation Proteolysis SERA5 Serine - metabolism
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