Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

Telomerase activation protects cells from telomere damage by delaying senescence and inducing cell immortalization, whereas telomerase inhibition mediates rapid senescence or apoptosis. However, the cellular mechanisms that determine telomere damage–dependent senescence versus apoptosis induction ar...

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Veröffentlicht in:	The Journal of biological chemistry 2018-06, Vol.293 (25), p.9784-9800
Hauptverfasser:	Panneer Selvam, Shanmugam, Roth, Braden M., Nganga, Rose, Kim, Jisun, Cooley, Marion A., Helke, Kristi, Smith, Charles D., Ogretmen, Besim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase 3 - genetics Caspase 3 - metabolism Cell Proliferation Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Female Humans Lipids Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lysophospholipids - metabolism Mice Mice, Knockout Mice, SCID Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Phosphotransferases (Alcohol Group Acceptor) - physiology senescence signal transduction sphingolipid Sphingosine - analogs & derivatives Sphingosine - metabolism sphingosine-1-phosphate (S1P) telomerase reverse transcriptase (TERT) Telomere - genetics Telomere - pathology Tumor Cells, Cultured Xenograft Model Antitumor Assays
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