Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study
Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women. A c...
Gespeichert in:
| Veröffentlicht in: | Ethiopian journal of health sciences 2018-05, Vol.28 (3), p.331-340 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 340 |
|---|---|
| container_issue | 3 |
| container_start_page | 331 |
| container_title | Ethiopian journal of health sciences |
| container_volume | 28 |
| creator | Alemu, Aynadis Abebe, Molla Biadgo, Belete Terefe, Betelihem Baynes, Habtamu Wondifraw |
| description | Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April, 2015. Fasting blood sample was collected from 139 pregnant and 139 age matched non-pregnant women using systematic random sampling technique. Interviewer-administered questionnaire was used to collect socio-demographic and clinical data. Fasting blood glucose and lipid profile were measured by A25 Biosytemchemistry analyzer using enzymatic calorimetric methods. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. A p-value of |
| doi_str_mv | 10.4314/ejhs.v28i3.11 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6016350</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>29983533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-dd4fec4ea8d6865df14987cc106dd0db22fa393e2ae6e81a8f10f7a0395ca4083</originalsourceid><addsrcrecordid>eNpVUcFu1DAQtRCIrtoeuSJ_AFns2EkcDkjLqrRIValUKo7W1J5sXCV2ZLtb7dfwqySUVjCXGc2892ZGj5B3nK2l4PIj3vdpvS-VE2vOX5FVKbkoGt6w12TFWdkWXFXNETlN6Z4t0bBairfkqGxbJSohVuTXFxdMj6MzMNDrGDo3YKKhm2vcefCZgrf0Kvhiem78DCN6uskZvXV-RyHT3CO99W6PMbl8WOjnwVuI9CKkyWUYPswSMfePmDI9y70Lk4NPdEO3YZwgQp6pdBtDSkVCk13w8zU3-cEeTsibDoaEp3_zMbn9evZje1Fcfj__tt1cFkZIlQtrZYdGIihbq7qyHZetaozhrLaW2buy7EC0AkvAGhUH1XHWNcBEWxmQTIlj8vlJd3q4G9Ea9DnCoKfoRogHHcDp_yfe9XoX9rpmvBYVmwWKJwGzvBGxe-Fyphez9GKW_mOW5nzGv_934Qv62RrxGw5QlnI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>African Journals Online (Open Access)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Alemu, Aynadis ; Abebe, Molla ; Biadgo, Belete ; Terefe, Betelihem ; Baynes, Habtamu Wondifraw</creator><creatorcontrib>Alemu, Aynadis ; Abebe, Molla ; Biadgo, Belete ; Terefe, Betelihem ; Baynes, Habtamu Wondifraw</creatorcontrib><description>Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April, 2015. Fasting blood sample was collected from 139 pregnant and 139 age matched non-pregnant women using systematic random sampling technique. Interviewer-administered questionnaire was used to collect socio-demographic and clinical data. Fasting blood glucose and lipid profile were measured by A25 Biosytemchemistry analyzer using enzymatic calorimetric methods. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. A p-value of <0.05 was considered as statistically significant.
Pregnant women as compared to non-pregnant had significantly increased glucose (96.35±14.45 and 81.12±9.86 mg/dl), total cholesterol (211.9±40.88 and 172.40±29.64 mg/dl) [p<0.05], respectively. It had also significantly high triglycerides (190.81±81.04 and 107.43±45.80 mg/dl) and low-density lipoprotein cholesterol (116.03±37.26 and 86.12±27.29mg/dl) [p<05] in pregnant as compared to non-pregnant women. The level of high-density lipoprotein cholesterol was significantly lower in pregnant women (59.58±14.26) than control (63.63±11.4, P <0.05).
There were statistically significant increment in glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol and decrement in high-density lipoprote in cholesterol levels among pregnant women compared with non-pregnant women. Therefore, pregnant women have to be monitored closely for their biochemical profiles to avoid adverse pregnancy outcomes.</description><identifier>ISSN: 1029-1857</identifier><identifier>EISSN: 2413-7170</identifier><identifier>EISSN: 1029-1857</identifier><identifier>DOI: 10.4314/ejhs.v28i3.11</identifier><identifier>PMID: 29983533</identifier><language>eng</language><publisher>Ethiopia: Research and Publications Office of Jimma University</publisher><subject>Adult ; Blood Glucose - metabolism ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Sectional Studies ; Dyslipidemias - blood ; Dyslipidemias - complications ; Ethiopia ; Female ; Hospitals ; Humans ; Hyperglycemia - blood ; Hyperglycemia - complications ; Original ; Pregnancy ; Pregnancy Complications - blood ; Prenatal Care ; Risk Factors ; Triglycerides - blood</subject><ispartof>Ethiopian journal of health sciences, 2018-05, Vol.28 (3), p.331-340</ispartof><rights>2018 Aynadis Alemu, et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-dd4fec4ea8d6865df14987cc106dd0db22fa393e2ae6e81a8f10f7a0395ca4083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016350/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016350/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29983533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alemu, Aynadis</creatorcontrib><creatorcontrib>Abebe, Molla</creatorcontrib><creatorcontrib>Biadgo, Belete</creatorcontrib><creatorcontrib>Terefe, Betelihem</creatorcontrib><creatorcontrib>Baynes, Habtamu Wondifraw</creatorcontrib><title>Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study</title><title>Ethiopian journal of health sciences</title><addtitle>Ethiop J Health Sci</addtitle><description>Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April, 2015. Fasting blood sample was collected from 139 pregnant and 139 age matched non-pregnant women using systematic random sampling technique. Interviewer-administered questionnaire was used to collect socio-demographic and clinical data. Fasting blood glucose and lipid profile were measured by A25 Biosytemchemistry analyzer using enzymatic calorimetric methods. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. A p-value of <0.05 was considered as statistically significant.
Pregnant women as compared to non-pregnant had significantly increased glucose (96.35±14.45 and 81.12±9.86 mg/dl), total cholesterol (211.9±40.88 and 172.40±29.64 mg/dl) [p<0.05], respectively. It had also significantly high triglycerides (190.81±81.04 and 107.43±45.80 mg/dl) and low-density lipoprotein cholesterol (116.03±37.26 and 86.12±27.29mg/dl) [p<05] in pregnant as compared to non-pregnant women. The level of high-density lipoprotein cholesterol was significantly lower in pregnant women (59.58±14.26) than control (63.63±11.4, P <0.05).
There were statistically significant increment in glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol and decrement in high-density lipoprote in cholesterol levels among pregnant women compared with non-pregnant women. Therefore, pregnant women have to be monitored closely for their biochemical profiles to avoid adverse pregnancy outcomes.</description><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Ethiopia</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - complications</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Prenatal Care</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><issn>1029-1857</issn><issn>2413-7170</issn><issn>1029-1857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcFu1DAQtRCIrtoeuSJ_AFns2EkcDkjLqrRIValUKo7W1J5sXCV2ZLtb7dfwqySUVjCXGc2892ZGj5B3nK2l4PIj3vdpvS-VE2vOX5FVKbkoGt6w12TFWdkWXFXNETlN6Z4t0bBairfkqGxbJSohVuTXFxdMj6MzMNDrGDo3YKKhm2vcefCZgrf0Kvhiem78DCN6uskZvXV-RyHT3CO99W6PMbl8WOjnwVuI9CKkyWUYPswSMfePmDI9y70Lk4NPdEO3YZwgQp6pdBtDSkVCk13w8zU3-cEeTsibDoaEp3_zMbn9evZje1Fcfj__tt1cFkZIlQtrZYdGIihbq7qyHZetaozhrLaW2buy7EC0AkvAGhUH1XHWNcBEWxmQTIlj8vlJd3q4G9Ea9DnCoKfoRogHHcDp_yfe9XoX9rpmvBYVmwWKJwGzvBGxe-Fyphez9GKW_mOW5nzGv_934Qv62RrxGw5QlnI</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Alemu, Aynadis</creator><creator>Abebe, Molla</creator><creator>Biadgo, Belete</creator><creator>Terefe, Betelihem</creator><creator>Baynes, Habtamu Wondifraw</creator><general>Research and Publications Office of Jimma University</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study</title><author>Alemu, Aynadis ; Abebe, Molla ; Biadgo, Belete ; Terefe, Betelihem ; Baynes, Habtamu Wondifraw</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-dd4fec4ea8d6865df14987cc106dd0db22fa393e2ae6e81a8f10f7a0395ca4083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Ethiopia</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Hyperglycemia - complications</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>Prenatal Care</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alemu, Aynadis</creatorcontrib><creatorcontrib>Abebe, Molla</creatorcontrib><creatorcontrib>Biadgo, Belete</creatorcontrib><creatorcontrib>Terefe, Betelihem</creatorcontrib><creatorcontrib>Baynes, Habtamu Wondifraw</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ethiopian journal of health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alemu, Aynadis</au><au>Abebe, Molla</au><au>Biadgo, Belete</au><au>Terefe, Betelihem</au><au>Baynes, Habtamu Wondifraw</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study</atitle><jtitle>Ethiopian journal of health sciences</jtitle><addtitle>Ethiop J Health Sci</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>28</volume><issue>3</issue><spage>331</spage><epage>340</epage><pages>331-340</pages><issn>1029-1857</issn><eissn>2413-7170</eissn><eissn>1029-1857</eissn><abstract>Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April, 2015. Fasting blood sample was collected from 139 pregnant and 139 age matched non-pregnant women using systematic random sampling technique. Interviewer-administered questionnaire was used to collect socio-demographic and clinical data. Fasting blood glucose and lipid profile were measured by A25 Biosytemchemistry analyzer using enzymatic calorimetric methods. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. A p-value of <0.05 was considered as statistically significant.
Pregnant women as compared to non-pregnant had significantly increased glucose (96.35±14.45 and 81.12±9.86 mg/dl), total cholesterol (211.9±40.88 and 172.40±29.64 mg/dl) [p<0.05], respectively. It had also significantly high triglycerides (190.81±81.04 and 107.43±45.80 mg/dl) and low-density lipoprotein cholesterol (116.03±37.26 and 86.12±27.29mg/dl) [p<05] in pregnant as compared to non-pregnant women. The level of high-density lipoprotein cholesterol was significantly lower in pregnant women (59.58±14.26) than control (63.63±11.4, P <0.05).
There were statistically significant increment in glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol and decrement in high-density lipoprote in cholesterol levels among pregnant women compared with non-pregnant women. Therefore, pregnant women have to be monitored closely for their biochemical profiles to avoid adverse pregnancy outcomes.</abstract><cop>Ethiopia</cop><pub>Research and Publications Office of Jimma University</pub><pmid>29983533</pmid><doi>10.4314/ejhs.v28i3.11</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1029-1857 |
| ispartof | Ethiopian journal of health sciences, 2018-05, Vol.28 (3), p.331-340 |
| issn | 1029-1857 2413-7170 1029-1857 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6016350 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; African Journals Online (Open Access); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Blood Glucose - metabolism Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Sectional Studies Dyslipidemias - blood Dyslipidemias - complications Ethiopia Female Hospitals Humans Hyperglycemia - blood Hyperglycemia - complications Original Pregnancy Pregnancy Complications - blood Prenatal Care Risk Factors Triglycerides - blood |
| title | Biochemical Profiles of Pregnant and Non-pregnant Women Attending at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-sectional Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T04%3A31%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biochemical%20Profiles%20of%20Pregnant%20and%20Non-pregnant%20Women%20Attending%20at%20the%20University%20of%20Gondar%20Hospital,%20Northwest%20Ethiopia:%20A%20Comparative%20Cross-sectional%20Study&rft.jtitle=Ethiopian%20journal%20of%20health%20sciences&rft.au=Alemu,%20Aynadis&rft.date=2018-05-01&rft.volume=28&rft.issue=3&rft.spage=331&rft.epage=340&rft.pages=331-340&rft.issn=1029-1857&rft.eissn=2413-7170&rft_id=info:doi/10.4314/ejhs.v28i3.11&rft_dat=%3Cpubmed_cross%3E29983533%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/29983533&rfr_iscdi=true |