Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis?
The keystone periodontal pathogen produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from can affect a number of mammalian cellular functions, such as pot...
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| creator | Olsen, Ingar Nichols, Frank C |
| description | The keystone periodontal pathogen
produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from
can affect a number of mammalian cellular functions, such as potentiation of prostaglandin secretion from gingival fibroblasts, promotion of RANKL-induced osteoclastogenesis, promotion of apoptosis, and enhancement of autoimmunity. In
, these lipids affect anchoring of surface polysaccharides, resistance to oxidative stress, and presentation of surface polysaccharides (anionic polysaccharides and K-antigen capsule). In addition to phosphorylated dihydroceramide lipids, serine dipeptide lipids of
are implicated in alveolar bone loss in chronic periodontitis through interference with osteoblast differentiation and function and promotion of osteoclast activity. As a prerequisite for designation as bacterial virulence factors, bacterial sphingolipids and serine dipeptide lipids are recovered in gingival/periodontal tissues, tooth calculus, human blood, vascular tissues, and brain. In addition to
, other bacteria of the genera
,
,
,
, and
produce sphingolipids and serine dipeptide lipids. The contribution of PDHCs and serine dipeptide lipids to the pathogenesis of periodontal and extraoral diseases may be an underappreciated area in microbe-host interaction and should be more intensively investigated. |
| doi_str_mv | 10.1128/iai.00035-18 |
| format | Article |
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produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from
can affect a number of mammalian cellular functions, such as potentiation of prostaglandin secretion from gingival fibroblasts, promotion of RANKL-induced osteoclastogenesis, promotion of apoptosis, and enhancement of autoimmunity. In
, these lipids affect anchoring of surface polysaccharides, resistance to oxidative stress, and presentation of surface polysaccharides (anionic polysaccharides and K-antigen capsule). In addition to phosphorylated dihydroceramide lipids, serine dipeptide lipids of
are implicated in alveolar bone loss in chronic periodontitis through interference with osteoblast differentiation and function and promotion of osteoclast activity. As a prerequisite for designation as bacterial virulence factors, bacterial sphingolipids and serine dipeptide lipids are recovered in gingival/periodontal tissues, tooth calculus, human blood, vascular tissues, and brain. In addition to
, other bacteria of the genera
,
,
,
, and
produce sphingolipids and serine dipeptide lipids. The contribution of PDHCs and serine dipeptide lipids to the pathogenesis of periodontal and extraoral diseases may be an underappreciated area in microbe-host interaction and should be more intensively investigated.</description><identifier>ISSN: 0019-9567</identifier><identifier>EISSN: 1098-5522</identifier><identifier>DOI: 10.1128/iai.00035-18</identifier><identifier>PMID: 29632248</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Alveolar Bone Loss - etiology ; Ceramides - chemistry ; Ceramides - physiology ; Chronic Periodontitis - etiology ; Humans ; Lipopeptides - chemistry ; Lipopeptides - physiology ; Minireview ; Osteoclasts - physiology ; Phosphorylation ; Porphyromonas gingivalis - pathogenicity ; Toll-Like Receptor 2 - physiology ; Virulence Factors - chemistry ; Virulence Factors - physiology</subject><ispartof>Infection and immunity, 2018-07, Vol.86 (7)</ispartof><rights>Copyright © 2018 American Society for Microbiology.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>Copyright © 2018 American Society for Microbiology. 2018 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-af0ab2630586bdeb117ae8b1072fed2b777533bd0a26544be1d0cd174059c3b13</citedby><cites>FETCH-LOGICAL-c474t-af0ab2630586bdeb117ae8b1072fed2b777533bd0a26544be1d0cd174059c3b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013676/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013676/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,26567,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29632248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Maurelli, Anthony T.</contributor><creatorcontrib>Olsen, Ingar</creatorcontrib><creatorcontrib>Nichols, Frank C</creatorcontrib><title>Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis?</title><title>Infection and immunity</title><addtitle>Infect Immun</addtitle><description>The keystone periodontal pathogen
produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from
can affect a number of mammalian cellular functions, such as potentiation of prostaglandin secretion from gingival fibroblasts, promotion of RANKL-induced osteoclastogenesis, promotion of apoptosis, and enhancement of autoimmunity. In
, these lipids affect anchoring of surface polysaccharides, resistance to oxidative stress, and presentation of surface polysaccharides (anionic polysaccharides and K-antigen capsule). In addition to phosphorylated dihydroceramide lipids, serine dipeptide lipids of
are implicated in alveolar bone loss in chronic periodontitis through interference with osteoblast differentiation and function and promotion of osteoclast activity. As a prerequisite for designation as bacterial virulence factors, bacterial sphingolipids and serine dipeptide lipids are recovered in gingival/periodontal tissues, tooth calculus, human blood, vascular tissues, and brain. In addition to
, other bacteria of the genera
,
,
,
, and
produce sphingolipids and serine dipeptide lipids. The contribution of PDHCs and serine dipeptide lipids to the pathogenesis of periodontal and extraoral diseases may be an underappreciated area in microbe-host interaction and should be more intensively investigated.</description><subject>Alveolar Bone Loss - etiology</subject><subject>Ceramides - chemistry</subject><subject>Ceramides - physiology</subject><subject>Chronic Periodontitis - etiology</subject><subject>Humans</subject><subject>Lipopeptides - chemistry</subject><subject>Lipopeptides - physiology</subject><subject>Minireview</subject><subject>Osteoclasts - physiology</subject><subject>Phosphorylation</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Toll-Like Receptor 2 - physiology</subject><subject>Virulence Factors - chemistry</subject><subject>Virulence Factors - physiology</subject><issn>0019-9567</issn><issn>1098-5522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNpVkc1vEzEQxS1ERUPhxhl87IEt_rb3AopaSiNFAqmUq2WvZxPDxl7sTaX-92xJW8FpNJqn37yZh9AbSs4oZeZDdPGMEMJlQ80ztKCkNY2UjD1HC0Jo27RS6WP0stafcyuEMC_QMWsVZ0yYBfq1LICvx21MmzzEMYaKXQr4GkpMgC_iCOMUA-D1YXaTAhSoU9y5CQL-Ect-gNQBvnTdlEvFucffchm3dyXvcnIVb2ZyvHVDrJ9eoaPeDRVeP9QTdHP5-fv5VbP--mV1vlw3ndBialxPnGeKE2mUD-Ap1Q6Mp0SzHgLzWmvJuQ_EMSWF8EAD6QLVgsi2457yE_TxwB33fgehgzQVN9ixzK7Lnc0u2v8nKW7tJt9aRShXWs2AdwdAV-J8a7IpF2cpMZJZJYwUs-L0YUXJv_fzQ-wu1g6GwSXI-2oZYVwzY8y9m_ePsFxrgf7JCCX2PkG7Wq7s3wQtNbP87b_mn8SPkfE_x5aYBg</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Olsen, Ingar</creator><creator>Nichols, Frank C</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis?</title><author>Olsen, Ingar ; Nichols, Frank C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-af0ab2630586bdeb117ae8b1072fed2b777533bd0a26544be1d0cd174059c3b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alveolar Bone Loss - etiology</topic><topic>Ceramides - chemistry</topic><topic>Ceramides - physiology</topic><topic>Chronic Periodontitis - etiology</topic><topic>Humans</topic><topic>Lipopeptides - chemistry</topic><topic>Lipopeptides - physiology</topic><topic>Minireview</topic><topic>Osteoclasts - physiology</topic><topic>Phosphorylation</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><topic>Toll-Like Receptor 2 - physiology</topic><topic>Virulence Factors - chemistry</topic><topic>Virulence Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, Ingar</creatorcontrib><creatorcontrib>Nichols, Frank C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, Ingar</au><au>Nichols, Frank C</au><au>Maurelli, Anthony T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis?</atitle><jtitle>Infection and immunity</jtitle><addtitle>Infect Immun</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>86</volume><issue>7</issue><issn>0019-9567</issn><eissn>1098-5522</eissn><abstract>The keystone periodontal pathogen
produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from
can affect a number of mammalian cellular functions, such as potentiation of prostaglandin secretion from gingival fibroblasts, promotion of RANKL-induced osteoclastogenesis, promotion of apoptosis, and enhancement of autoimmunity. In
, these lipids affect anchoring of surface polysaccharides, resistance to oxidative stress, and presentation of surface polysaccharides (anionic polysaccharides and K-antigen capsule). In addition to phosphorylated dihydroceramide lipids, serine dipeptide lipids of
are implicated in alveolar bone loss in chronic periodontitis through interference with osteoblast differentiation and function and promotion of osteoclast activity. As a prerequisite for designation as bacterial virulence factors, bacterial sphingolipids and serine dipeptide lipids are recovered in gingival/periodontal tissues, tooth calculus, human blood, vascular tissues, and brain. In addition to
, other bacteria of the genera
,
,
,
, and
produce sphingolipids and serine dipeptide lipids. The contribution of PDHCs and serine dipeptide lipids to the pathogenesis of periodontal and extraoral diseases may be an underappreciated area in microbe-host interaction and should be more intensively investigated.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>29632248</pmid><doi>10.1128/iai.00035-18</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; NORA - Norwegian Open Research Archives; American Society for Microbiology Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alveolar Bone Loss - etiology Ceramides - chemistry Ceramides - physiology Chronic Periodontitis - etiology Humans Lipopeptides - chemistry Lipopeptides - physiology Minireview Osteoclasts - physiology Phosphorylation Porphyromonas gingivalis - pathogenicity Toll-Like Receptor 2 - physiology Virulence Factors - chemistry Virulence Factors - physiology |
| title | Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis? |
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