CRAN-26. COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT

CRAN-26. COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT

Abstract BACKGROUND The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD This is a retrospective review and children with oncolog...

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Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Va.), 2018-06, Vol.20 (suppl_2), p.i42-i42
Hauptverfasser: Chan, Godfrey Chi-Fung, Ku, Dennis Tak-Noi, Luk, Chun Wing, Ling, Alvin Siu-Cheung, Shing, Matthew Ming-Kong, Liu, Anthony Pak-Yin
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container_issue suppl_2
container_start_page i42
container_title Neuro-oncology (Charlottesville, Va.)
container_volume 20
creator Chan, Godfrey Chi-Fung
Ku, Dennis Tak-Noi
Luk, Chun Wing
Ling, Alvin Siu-Cheung
Shing, Matthew Ming-Kong
Liu, Anthony Pak-Yin
description Abstract BACKGROUND The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT From Jan 1994 to Dec 2016 (13-yrs), 21 children (
doi_str_mv 10.1093/neuonc/noy059.062
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COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chan, Godfrey Chi-Fung ; Ku, Dennis Tak-Noi ; Luk, Chun Wing ; Ling, Alvin Siu-Cheung ; Shing, Matthew Ming-Kong ; Liu, Anthony Pak-Yin</creator><creatorcontrib>Chan, Godfrey Chi-Fung ; Ku, Dennis Tak-Noi ; Luk, Chun Wing ; Ling, Alvin Siu-Cheung ; Shing, Matthew Ming-Kong ; Liu, Anthony Pak-Yin</creatorcontrib><description>Abstract BACKGROUND The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT From Jan 1994 to Dec 2016 (13-yrs), 21 children (&lt;18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children&lt;15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noy059.062</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Abstracts</subject><ispartof>Neuro-oncology (Charlottesville, Va.), 2018-06, Vol.20 (suppl_2), p.i42-i42</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012806/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012806/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1578,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Chan, Godfrey Chi-Fung</creatorcontrib><creatorcontrib>Ku, Dennis Tak-Noi</creatorcontrib><creatorcontrib>Luk, Chun Wing</creatorcontrib><creatorcontrib>Ling, Alvin Siu-Cheung</creatorcontrib><creatorcontrib>Shing, Matthew Ming-Kong</creatorcontrib><creatorcontrib>Liu, Anthony Pak-Yin</creatorcontrib><title>CRAN-26. COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>Abstract BACKGROUND The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT From Jan 1994 to Dec 2016 (13-yrs), 21 children (&lt;18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children&lt;15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. 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COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT</title><author>Chan, Godfrey Chi-Fung ; Ku, Dennis Tak-Noi ; Luk, Chun Wing ; Ling, Alvin Siu-Cheung ; Shing, Matthew Ming-Kong ; Liu, Anthony Pak-Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1772-9d15e3e0d63877ee41ee107b27d552f22de013ced5451789809da95e3f670e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abstracts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Godfrey Chi-Fung</creatorcontrib><creatorcontrib>Ku, Dennis Tak-Noi</creatorcontrib><creatorcontrib>Luk, Chun Wing</creatorcontrib><creatorcontrib>Ling, Alvin Siu-Cheung</creatorcontrib><creatorcontrib>Shing, Matthew Ming-Kong</creatorcontrib><creatorcontrib>Liu, Anthony Pak-Yin</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Godfrey Chi-Fung</au><au>Ku, Dennis Tak-Noi</au><au>Luk, Chun Wing</au><au>Ling, Alvin Siu-Cheung</au><au>Shing, Matthew Ming-Kong</au><au>Liu, Anthony Pak-Yin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CRAN-26. COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2018-06-22</date><risdate>2018</risdate><volume>20</volume><issue>suppl_2</issue><spage>i42</spage><epage>i42</epage><pages>i42-i42</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Abstract BACKGROUND The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT From Jan 1994 to Dec 2016 (13-yrs), 21 children (&lt;18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children&lt;15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/neuonc/noy059.062</doi><oa>free_for_read</oa></addata></record>
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title CRAN-26. COMPARING SURGERY ALONE OR SURGERY PLUS RADIATION THERAPY IN CRANIOPHARYNGIOMA MANAGEMENT
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