LGG-59. REMARKABLE OBJECTIVE RESPONSE AND FAVORABLE SURVIVAL FOR BRAF-V600E CHILDHOOD LOW-GRADE GLIOMAS TO BRAF INHIBITORS COMPARED CONVENTIONAL CHEMOTHERAPY

Abstract Activation of the MAPK pathway represents a hallmark of pediatric low-grade glioma (pLGG) and is frequently caused by BRAF alterations. BRAF-V600E represent an aggressive type of pLGG with less than optimal response to conventional chemo-radiation approaches. While clinical trials using BRA...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2018-06, Vol.20 (suppl_2), p.i117-i117
Hauptverfasser:	Zapotocky, Michal, Ryall, Scott, Fukuoka, Kohei, Stucklin, Ana Guerreiro, Bennett, Julie, Sumerauer, David, Pavelka, Zdenek, Cruz, Ofelia, Solano, Palma, Garre, Maria Luisa, Hauser, Peter, Frappaz, Didier, Hansford, Jordan, Amayiri, Nisreen, Morse, Helena, Sabel, Magnus, Bechensteen, Anne Grete, Su, Jack, Karajannis, Matthias, Finlay, Jonathan, Eisenstat, David, Canete, Adela, Toledano, Helen, Dahiya, Sonika, Leary, Sarah, Nicolaides, Theodore, Finch, Elisabeth, Mueller, Sabine, Levy, Jean Mulcahy, Ellison, David, Lassaletta, Alvaro, Larouche, Valerie, Ramaswamy, Vijay, Dirks, Peter, McKeown, Tara, Bartels, Ute, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstracts
Online-Zugang:	Volltext
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