Salinomycin-loaded Nanofibers for Glioblastoma Therapy

Salinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by electrospinning for the first time. The biodegradable PLGA NFs had stability for approximately 30 days and e...

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Veröffentlicht in:	Scientific reports 2018-06, Vol.8 (1), p.9377-10, Article 9377
Hauptverfasser:	Norouzi, Mohammad, Abdali, Zahra, Liu, Song, Miller, Donald W.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/28 14/63 38/77 631/67/1059/99 692/4028/67/1059/99 Antitumor agents Apoptosis Biodegradability Biodegradation Brain cancer Cancer Caspase Caspase-3 Controlled release Cytotoxicity Drug delivery Gene expression Glioblastoma Humanities and Social Sciences multidisciplinary Polylactide-co-glycolide Reactive oxygen species Salinomycin Science Science (multidisciplinary) Signal transduction Tumor suppressor genes Wnt protein
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