Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐O‐sulfate in rats: Drug discrimination and physical dependence

Morphine‐6‐O‐sulfate (M6S) is as a mixed‐action mu/delta (μ/δ) opioid receptor agonist with high potency and analgesic efficacy. These studies used assays of drug discrimination and schedule‐controlled responding to assess abuse‐liability, tolerance, and physical dependence as compared to morphine i...

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Veröffentlicht in:	Pharmacology research & perspectives 2018-07, Vol.6 (4), p.e00403-n/a
Hauptverfasser:	Yadlapalli, Jai Shankar K., Bommagani, Shoban Babu, Mahelona, Ryan D., Wan, Anqi, Gannon, Brenda M., Penthala, Narsimha R., Dobretsov, Maxim, Crooks, Peter A., Fantegrossi, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	abuse liability Analgesics Analgesics, Opioid - pharmacology Animals Binding sites Conditioning, Operant delta opioid receptor (DOR) Diabetes Diabetic neuropathy Discrimination Learning drug discrimination Drug dosages Drug Tolerance Experiments Laboratory animals Male mixed‐action mu/delta opioids Morphine Morphine Derivatives - pharmacology morphine‐6‐O‐sulfate (M6S) mu opioid receptor (MOR) Naltrexone - pharmacology Narcotic Antagonists - pharmacology Narcotics Opioid-Related Disorders Original Pain Pharmaceutical sciences Pharmacology Pharmacy physical dependence Rats, Sprague-Dawley Receptors, Opioid, delta - agonists Receptors, Opioid, mu - agonists Response rates Substance Withdrawal Syndrome Variance analysis
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