No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty
Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) wit...
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| description | Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group. |
| doi_str_mv | 10.1155/2018/3687415 |
| format | Article |
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D. ; Jäger, Marcus ; Dudda, Marcel ; Gehrke, Thorsten ; Bachmann, Hagen Sjard ; Kurscheid, Gina ; Aydin-Yüce, Tünay ; Wedemeyer, Christian</creator><contributor>Weber, Patrick ; Patrick Weber</contributor><creatorcontrib>Kauther, M. D. ; Jäger, Marcus ; Dudda, Marcel ; Gehrke, Thorsten ; Bachmann, Hagen Sjard ; Kurscheid, Gina ; Aydin-Yüce, Tünay ; Wedemeyer, Christian ; Weber, Patrick ; Patrick Weber</creatorcontrib><description>Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/3687415</identifier><identifier>PMID: 29967770</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Aged ; Alternative splicing ; Arthroplasty, Replacement, Hip ; Biomedical materials ; Body mass ; Bone implants ; Calcitonin ; Calcitonin gene-related peptide ; Calcitonin Gene-Related Peptide - genetics ; Cementation ; Cytokines ; Deoxyribonucleic acid ; Diabetic retinopathy ; DNA ; Female ; Gender ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Hip ; Hip Prosthesis ; Humans ; Implantation ; Joint surgery ; Loosening ; Male ; Middle Aged ; Neuropeptides ; Patients ; Peptides ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Prosthesis Failure ; Statistical analysis ; Surgical implants ; Total hip arthroplasty ; Transplants & implants</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-7</ispartof><rights>Copyright © 2018 Tünay Aydin-Yüce et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Tünay Aydin-Yüce et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Tünay Aydin-Yüce et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-ddba0c7e68a08cd6bccac0c8a4b55bd6e225f176ff13f894213ea11c0b0e6aab3</citedby><cites>FETCH-LOGICAL-c499t-ddba0c7e68a08cd6bccac0c8a4b55bd6e225f176ff13f894213ea11c0b0e6aab3</cites><orcidid>0000-0002-8642-540X ; 0000-0003-3795-6068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008809/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008809/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29967770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Weber, Patrick</contributor><contributor>Patrick Weber</contributor><creatorcontrib>Kauther, M. D.</creatorcontrib><creatorcontrib>Jäger, Marcus</creatorcontrib><creatorcontrib>Dudda, Marcel</creatorcontrib><creatorcontrib>Gehrke, Thorsten</creatorcontrib><creatorcontrib>Bachmann, Hagen Sjard</creatorcontrib><creatorcontrib>Kurscheid, Gina</creatorcontrib><creatorcontrib>Aydin-Yüce, Tünay</creatorcontrib><creatorcontrib>Wedemeyer, Christian</creatorcontrib><title>No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group.</description><subject>Age</subject><subject>Aged</subject><subject>Alternative splicing</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Biomedical materials</subject><subject>Body mass</subject><subject>Bone implants</subject><subject>Calcitonin</subject><subject>Calcitonin gene-related peptide</subject><subject>Calcitonin Gene-Related Peptide - genetics</subject><subject>Cementation</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetic retinopathy</subject><subject>DNA</subject><subject>Female</subject><subject>Gender</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hip</subject><subject>Hip Prosthesis</subject><subject>Humans</subject><subject>Implantation</subject><subject>Joint surgery</subject><subject>Loosening</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropeptides</subject><subject>Patients</subject><subject>Peptides</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prosthesis Failure</subject><subject>Statistical analysis</subject><subject>Surgical implants</subject><subject>Total hip arthroplasty</subject><subject>Transplants & implants</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1vEzEQxS0EolXpjTOyxAUJQv2x6_VekFYRpUgR9FDOZtZrJ6527cV2QPnv6yghBU74YI_kn97MvIfQS0reU1rXV4xQecWFbCpaP0HnjNNqIWhFn55qzs_QZUr3pBxJBWnFc3TG2lY0TUPO0fcvAXcpBe0gu-BxsHjZrZYdvg3jbgpx3rg0JQx-KJiZs9N4FUIy3vk1BptNxLfRTRB3-C5kGPGNm3EX8yaGeYSUdy_QMwtjMpfH9wJ9u_54t7xZrL5--lxaLXTVtnkxDD0Q3RghgUg9iF5r0ERLqPq67gdhGKstbYS1lFvZVoxyA5Rq0hMjAHp-gT4cdOdtP5lBG58jjGo-DKcCOPX3j3cbtQ4_lSi-SNIWgTdHgRh-bE3KanJJm3EEb8I2KUYEb2hxmhT09T_ofdhGX9YrVN0QJgWrH6k1jEY5b0Ppq_eiqhOMSkLKVah3B0rHkFI09jQyJWqfsdpnrI4ZF_zVn2ue4N-JFuDtAdg4P8Av959ypjDGwiNN2d4Y_gBimLg-</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kauther, M. D.</creator><creator>Jäger, Marcus</creator><creator>Dudda, Marcel</creator><creator>Gehrke, Thorsten</creator><creator>Bachmann, Hagen Sjard</creator><creator>Kurscheid, Gina</creator><creator>Aydin-Yüce, Tünay</creator><creator>Wedemeyer, Christian</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8642-540X</orcidid><orcidid>https://orcid.org/0000-0003-3795-6068</orcidid></search><sort><creationdate>20180101</creationdate><title>No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty</title><author>Kauther, M. D. ; Jäger, Marcus ; Dudda, Marcel ; Gehrke, Thorsten ; Bachmann, Hagen Sjard ; Kurscheid, Gina ; Aydin-Yüce, Tünay ; Wedemeyer, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-ddba0c7e68a08cd6bccac0c8a4b55bd6e225f176ff13f894213ea11c0b0e6aab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Aged</topic><topic>Alternative splicing</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Biomedical materials</topic><topic>Body mass</topic><topic>Bone implants</topic><topic>Calcitonin</topic><topic>Calcitonin gene-related peptide</topic><topic>Calcitonin Gene-Related Peptide - genetics</topic><topic>Cementation</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetic retinopathy</topic><topic>DNA</topic><topic>Female</topic><topic>Gender</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hip</topic><topic>Hip Prosthesis</topic><topic>Humans</topic><topic>Implantation</topic><topic>Joint surgery</topic><topic>Loosening</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropeptides</topic><topic>Patients</topic><topic>Peptides</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prosthesis Failure</topic><topic>Statistical analysis</topic><topic>Surgical implants</topic><topic>Total hip arthroplasty</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kauther, M. 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D.</au><au>Jäger, Marcus</au><au>Dudda, Marcel</au><au>Gehrke, Thorsten</au><au>Bachmann, Hagen Sjard</au><au>Kurscheid, Gina</au><au>Aydin-Yüce, Tünay</au><au>Wedemeyer, Christian</au><au>Weber, Patrick</au><au>Patrick Weber</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29967770</pmid><doi>10.1155/2018/3687415</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8642-540X</orcidid><orcidid>https://orcid.org/0000-0003-3795-6068</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aged Alternative splicing Arthroplasty, Replacement, Hip Biomedical materials Body mass Bone implants Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - genetics Cementation Cytokines Deoxyribonucleic acid Diabetic retinopathy DNA Female Gender Gene polymorphism Genes Genetic aspects Genetic Predisposition to Disease Genotype Genotypes Hip Hip Prosthesis Humans Implantation Joint surgery Loosening Male Middle Aged Neuropeptides Patients Peptides Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Prosthesis Failure Statistical analysis Surgical implants Total hip arthroplasty Transplants & implants |
| title | No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
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