A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression

In mucosal inflammatory disorders, the protective influence of heme oxygenase-1 (HO-1) and its metabolic byproducts, carbon monoxide (CO) and biliverdin, is a topic of significant interest. Mechanisms under investigation include the regulation of macrophage function and mucosal cytokine expression....

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Veröffentlicht in:	Journal of innate immunity 2018-01, Vol.10 (3), p.228-238
Hauptverfasser:	Onyiah, Joseph C., Schaefer, Rachel E.M., Colgan, Sean P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Cell Line, Tumor Chemokines - genetics Chemokines - metabolism Colitis - metabolism Colitis - pathology Dactinomycin - pharmacology Gene Knockdown Techniques Heme - analogs & derivatives Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Leukocytes - metabolism Leukocytes - microbiology Research Article Salmonella typhimurium - physiology THP-1 Cells Transcription, Genetic - drug effects
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