Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults

Abstract Recent work has begun to shed light on the neural correlates and possible mechanisms of polygenic risk for schizophrenia. Here, we map a schizophrenia polygenic risk profile score (PRS) based on genome-wide association study significant loci onto variability in the activity and functional c...

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Veröffentlicht in:	Schizophrenia bulletin 2018-06, Vol.44 (4), p.844-853
Hauptverfasser:	Miller, Jacob A, Scult, Matthew A, Conley, Emily Drabant, Chen, Qiang, Weinberger, Daniel R, Hariri, Ahmad R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Female Genome-Wide Association Study Humans Magnetic Resonance Imaging Male Memory, Short-Term - physiology Multifactorial Inheritance Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Regular Schizophrenia - genetics Young Adult
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