Reduced vasorin enhances angiotensin II signaling within the aging arterial wall

The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in the vascular smooth muscle cells (VSMCs) of the arterial wall. Angiotensin II (Ang II) amplifies TGF-β1 activation in the VSMCs of the arte...

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Veröffentlicht in:	Oncotarget 2018-06, Vol.9 (43), p.27117-27132
Hauptverfasser:	Pintus, Gianfranco, Giordo, Roberta, Wang, Yushi, Zhu, Wanqu, Kim, Soo Hyuk, Zhang, Li, Ni, Leng, Zhang, Jing, Telljohann, Richard, McGraw, Kimberly R, Monticone, Robert E, Ferris, Chloe, Liu, Lijuan, Wang, Mingyi, Lakatta, Edward G
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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