Synovial fluid uric acid level aids diagnosis of gout
Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SS...
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| Veröffentlicht in: | Biomedical reports 2018-07, Vol.9 (1), p.60-64 |
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| creator | Vaidya, Binit Bhochhibhoya, Manisha Nakarmi, Shweta |
| description | Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting with acute ( |
| doi_str_mv | 10.3892/br.2018.1097 |
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SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting with acute (<1 day) joint pain and/or swelling were included. Aspiration was performed in all patients and fluid was subjected to testing for urate level, pH and cell counts and microscopy. Serum samples were also assessed for urate levels, and the SSR was calculated for each patient. A receiver operating characteristic curve was plotted to determine the cutoff value for indicating diagnosis of gout. The difference in SSR between gout and non-gout effusion was evaluated by one-way analysis of variance. A total of 181 patients were included of which 77 had gout. The remaining cases included osteoarthritis, pseudogout, rheumatoid arthritis and ankylosing spondylitis. SSR was significantly higher in gout patients than in any other group (P<0.05). An SSR of ≥1.01 had the highest sensitivity and specificity at 89.6 and 66.3%, respectively, for identifying gout effusion. The present results indicated that SSR may be used as an aid for gout diagnosis when polarizing microscopy is not available.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2018.1097</identifier><identifier>PMID: 29930806</identifier><language>eng</language><publisher>England: Spandidos Publications</publisher><subject>Ankylosing spondylitis ; Arthritis ; Biocompatibility ; Biomedical materials ; Care and treatment ; Chondrocalcinosis ; Cross-sectional studies ; Development and progression ; Diagnosis ; Effusion ; Gout ; Health aspects ; Laboratories ; Microscopy ; Osteoarthritis ; Pain ; Patients ; Rheumatic diseases ; Rheumatism ; Rheumatoid arthritis ; Rheumatology ; Risk factors ; Spondylitis ; Standard deviation ; Synovial fluid ; Urate oxidase ; Uric acid ; Variance analysis</subject><ispartof>Biomedical reports, 2018-07, Vol.9 (1), p.60-64</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright © 2018, Spandidos Publications 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-558d73c38bbd1eb19d03215f1ac1ab3828ea80e4d1981aa030f9f8972c39d5583</citedby><cites>FETCH-LOGICAL-c505t-558d73c38bbd1eb19d03215f1ac1ab3828ea80e4d1981aa030f9f8972c39d5583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007039/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007039/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29930806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaidya, Binit</creatorcontrib><creatorcontrib>Bhochhibhoya, Manisha</creatorcontrib><creatorcontrib>Nakarmi, Shweta</creatorcontrib><title>Synovial fluid uric acid level aids diagnosis of gout</title><title>Biomedical reports</title><addtitle>Biomed Rep</addtitle><description>Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting with acute (<1 day) joint pain and/or swelling were included. Aspiration was performed in all patients and fluid was subjected to testing for urate level, pH and cell counts and microscopy. Serum samples were also assessed for urate levels, and the SSR was calculated for each patient. A receiver operating characteristic curve was plotted to determine the cutoff value for indicating diagnosis of gout. The difference in SSR between gout and non-gout effusion was evaluated by one-way analysis of variance. A total of 181 patients were included of which 77 had gout. The remaining cases included osteoarthritis, pseudogout, rheumatoid arthritis and ankylosing spondylitis. SSR was significantly higher in gout patients than in any other group (P<0.05). An SSR of ≥1.01 had the highest sensitivity and specificity at 89.6 and 66.3%, respectively, for identifying gout effusion. The present results indicated that SSR may be used as an aid for gout diagnosis when polarizing microscopy is not available.</description><subject>Ankylosing spondylitis</subject><subject>Arthritis</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Care and treatment</subject><subject>Chondrocalcinosis</subject><subject>Cross-sectional studies</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Effusion</subject><subject>Gout</subject><subject>Health aspects</subject><subject>Laboratories</subject><subject>Microscopy</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>Patients</subject><subject>Rheumatic diseases</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Spondylitis</subject><subject>Standard deviation</subject><subject>Synovial fluid</subject><subject>Urate oxidase</subject><subject>Uric acid</subject><subject>Variance analysis</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkc1PJCEQxYlZo0a9eTadeNmDMxbQTFOXTYxRdxMTD-qZ0HyMGKZRmJ7E_36ZqOO6EQ5U4PceFI-QIwpTLpGd9XnKgMopBey2yB6DFifYtuzHpubtLjks5QnqwA6YkDtklyFykDDbI-LudUiroGPj4xhsM-ZgGm1qFd3KxUYHWxob9HxIJZQm-WaexuUB2fY6Fnf4vu6Th6vL-4vfk5vb6z8X5zcTI0AsJ0JI23HDZd9b6nqKFjijwlNtqO65ZNJpCa61FCXVGjh49BI7ZjjaKub75Neb7_PYL5w1blhmHdVzDgudX1XSQX09GcKjmqeVmgF0wLEa_Hw3yOlldGWpFqEYF6MeXBqLYiBkfargvKIn_6FPacxDba9SiKxDKtknNdfRqTD4VO81a1N1Xm26GSCllZp-Q9Vp3SKYNDgf6v4XwembwORUSnZ-0yMFtU5a9Vmtk1brpCt-_O-_bOCPXPlfjfygyg</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Vaidya, Binit</creator><creator>Bhochhibhoya, Manisha</creator><creator>Nakarmi, Shweta</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Synovial fluid uric acid level aids diagnosis of gout</title><author>Vaidya, Binit ; Bhochhibhoya, Manisha ; Nakarmi, Shweta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-558d73c38bbd1eb19d03215f1ac1ab3828ea80e4d1981aa030f9f8972c39d5583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ankylosing spondylitis</topic><topic>Arthritis</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Care and treatment</topic><topic>Chondrocalcinosis</topic><topic>Cross-sectional studies</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Effusion</topic><topic>Gout</topic><topic>Health aspects</topic><topic>Laboratories</topic><topic>Microscopy</topic><topic>Osteoarthritis</topic><topic>Pain</topic><topic>Patients</topic><topic>Rheumatic diseases</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk factors</topic><topic>Spondylitis</topic><topic>Standard deviation</topic><topic>Synovial fluid</topic><topic>Urate oxidase</topic><topic>Uric acid</topic><topic>Variance analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Vaidya, Binit</creatorcontrib><creatorcontrib>Bhochhibhoya, Manisha</creatorcontrib><creatorcontrib>Nakarmi, Shweta</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaidya, Binit</au><au>Bhochhibhoya, Manisha</au><au>Nakarmi, Shweta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synovial fluid uric acid level aids diagnosis of gout</atitle><jtitle>Biomedical reports</jtitle><addtitle>Biomed Rep</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>9</volume><issue>1</issue><spage>60</spage><epage>64</epage><pages>60-64</pages><issn>2049-9434</issn><eissn>2049-9442</eissn><abstract>Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting with acute (<1 day) joint pain and/or swelling were included. Aspiration was performed in all patients and fluid was subjected to testing for urate level, pH and cell counts and microscopy. Serum samples were also assessed for urate levels, and the SSR was calculated for each patient. A receiver operating characteristic curve was plotted to determine the cutoff value for indicating diagnosis of gout. The difference in SSR between gout and non-gout effusion was evaluated by one-way analysis of variance. A total of 181 patients were included of which 77 had gout. The remaining cases included osteoarthritis, pseudogout, rheumatoid arthritis and ankylosing spondylitis. SSR was significantly higher in gout patients than in any other group (P<0.05). An SSR of ≥1.01 had the highest sensitivity and specificity at 89.6 and 66.3%, respectively, for identifying gout effusion. The present results indicated that SSR may be used as an aid for gout diagnosis when polarizing microscopy is not available.</abstract><cop>England</cop><pub>Spandidos Publications</pub><pmid>29930806</pmid><doi>10.3892/br.2018.1097</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ankylosing spondylitis Arthritis Biocompatibility Biomedical materials Care and treatment Chondrocalcinosis Cross-sectional studies Development and progression Diagnosis Effusion Gout Health aspects Laboratories Microscopy Osteoarthritis Pain Patients Rheumatic diseases Rheumatism Rheumatoid arthritis Rheumatology Risk factors Spondylitis Standard deviation Synovial fluid Urate oxidase Uric acid Variance analysis |
| title | Synovial fluid uric acid level aids diagnosis of gout |
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