Development and survival of Th17 cells within the intestines: the influence of microbiome- and diet-derived signals
Th17 cells have emerged as important mediators of host defense and homeostasis at barrier sites, particularly the intestines, where the greatest number and diversity of the microbiota reside. A critical balance exists between protection of the host from its own microbiota and pathogens and the devel...
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| Veröffentlicht in: | The Journal of immunology (1950) 2014-11, Vol.193 (10), p.4769-4777 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 193 |
| creator | Chewning, Joseph H Weaver, Casey T |
| description | Th17 cells have emerged as important mediators of host defense and homeostasis at barrier sites, particularly the intestines, where the greatest number and diversity of the microbiota reside. A critical balance exists between protection of the host from its own microbiota and pathogens and the development of immune-mediated disease. Breaches of local innate immune defenses provide critical stimuli for the induction of Th17 cell development, and additional cues within these tissues promote Th17 cell survival and/or plasticity. Normally, this results in eradication of the microbial threat and restitution of homeostasis. When dysregulated, however, Th17 cells can cause a range of immune-mediated diseases, whether directed against Ags derived from the microbiota, such as in inflammatory bowel disease, or against self-Ags in a range of autoimmune diseases. This review highlights recent discoveries that provide new insights into ways in which environmental signals impact Th17 cell development and function in the intestines. |
| doi_str_mv | 10.4049/jimmunol.1401835 |
| format | Article |
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This review highlights recent discoveries that provide new insights into ways in which environmental signals impact Th17 cell development and function in the intestines.</description><subject>Autoantigens - genetics</subject><subject>Autoantigens - immunology</subject><subject>Cell Survival</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - microbiology</subject><subject>Dendritic Cells - pathology</subject><subject>Diet</subject><subject>Gene Expression Regulation</subject><subject>Homeostasis - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Inflammatory Bowel Diseases - immunology</subject><subject>Inflammatory Bowel Diseases - microbiology</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Intestines - immunology</subject><subject>Intestines - microbiology</subject><subject>Intestines - pathology</subject><subject>Microbiota - immunology</subject><subject>Signal Transduction - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - microbiology</subject><subject>Th17 Cells - pathology</subject><issn>0022-1767</issn><issn>1550-6606</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxS1EBVvKnVOVI5fAjL-ScEBCtIVKSL3Qs-U4E9YosbdxEtT_nmxZEJx6Go383k9-8xg7QTiTIKvzR9_3U4jdGUrAUqg9tkKlINca9D5bAXCeY6GLQ_Y5pUcA0MDlATvkSpQoVLli6RvN1MVNT2HMbGiyNA2zn22XxTa7X2OROeq6lD35ce1DNq4p82GkNPpA6WK3t91EwdHW0ns3xNrHnvJ_uMbTmDc0-JkWtn8Itktf2Kd2GXS8m0fs94_v99e3-d2vm5_XV3e5k5Uac0dckZLgpBZKuVo2gLLgvCHlmkJZBLC2betCAIHUDmvUnIuCW6kEAoojdvnC3Ux1T41bIg62M5vB93b4a6L15uNL8GvzEGejAQpAWACnO8AQ_0xLaNP7tL2HDRSnZLCEUlcVCvF_qZagy0pAtUjhRbpcKqWB2rcfIZhtrea1VrOrdbF8fZ_kzfDao3gGH_yheg</recordid><startdate>20141115</startdate><enddate>20141115</enddate><creator>Chewning, Joseph H</creator><creator>Weaver, Casey T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20141115</creationdate><title>Development and survival of Th17 cells within the intestines: the influence of microbiome- and diet-derived signals</title><author>Chewning, Joseph H ; 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| issn | 0022-1767 1550-6606 1550-6606 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Autoantigens - genetics Autoantigens - immunology Cell Survival Cytokines - genetics Cytokines - immunology Dendritic Cells - immunology Dendritic Cells - microbiology Dendritic Cells - pathology Diet Gene Expression Regulation Homeostasis - immunology Humans Immunity, Innate Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Intestines - immunology Intestines - microbiology Intestines - pathology Microbiota - immunology Signal Transduction - immunology Th17 Cells - immunology Th17 Cells - microbiology Th17 Cells - pathology |
| title | Development and survival of Th17 cells within the intestines: the influence of microbiome- and diet-derived signals |
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