Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study
Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molec...
Gespeichert in:
| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2018-07, Vol.43 (8), p.1700-1705 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1705 |
|---|---|
| container_issue | 8 |
| container_start_page | 1700 |
| container_title | Neuropsychopharmacology (New York, N.Y.) |
| container_volume | 43 |
| creator | Hafizi, Sina Da Silva, Tania Meyer, Jeffrey H Kiang, Michael Houle, Sylvain Remington, Gary Prce, Ivana Wilson, Alan A Rusjan, Pablo M Sailasuta, Napapon Mizrahi, Romina |
| description | Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molecular mechanisms underlying this interaction are not yet understood. To date, no study has investigated this link in vivo in the human brain. We conducted the first in vivo study linking translocator protein 18 kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [
F]FEPPA, and 3T proton magnetic resonance spectroscopy (
H MRS). The omnibus model (including TSPO genotype as covariate) was significant (F
= 10.01, p |
| doi_str_mv | 10.1038/s41386-018-0061-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6006145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2038266852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-9f37198942ff319921689e9bfe6d7d8cd66854edb5460a0324617dc7aaddf3f23</originalsourceid><addsrcrecordid>eNpdkU9PFTEUxRsjkQf6AdyYJm7cVNppp9O6MDEElAQDkWfCrunrH15hpn20M-D79nbykKiru-i5557THwBvCf5IMBVHhREqOMJEIIw5Qe0LsCAdw4hTdv0SLLCQFBFKr_fBQSm3GJO24-IV2G9kxwSneAHKWRxd1mYMKcKVGx-di3B5dXmBNIxuyikMwxQdHHS-cxnpaGF2Nv2CZdTjVGCI0PQhBqN7uA43a5hDuYM-ZbgpW7NOJZRPUMPLkyX6_uOqbk12-xrsed0X9-ZpHoKfpyfL42_o_OLr2fGXc2SYpCOSnnZECska7ymRsiFcSCdX3nHbWWEs56Jlzq5axrHGtGGcdNZ0WlvrqW_oIfi8891Mq8FZ4-KYda82OdQ2W5V0UP--xLBWN-lB8fk3WVsNPjwZ5HQ_uTKqIRTj-l5Hl6aimgqhmVPMt97_J71NU461XlXxCoJhTKuK7FQmp1Ky889hCFYzUrVDqipSNYdQc4h3f7d43vjDkP4GDhedkw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2060894003</pqid></control><display><type>article</type><title>Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Hafizi, Sina ; Da Silva, Tania ; Meyer, Jeffrey H ; Kiang, Michael ; Houle, Sylvain ; Remington, Gary ; Prce, Ivana ; Wilson, Alan A ; Rusjan, Pablo M ; Sailasuta, Napapon ; Mizrahi, Romina</creator><creatorcontrib>Hafizi, Sina ; Da Silva, Tania ; Meyer, Jeffrey H ; Kiang, Michael ; Houle, Sylvain ; Remington, Gary ; Prce, Ivana ; Wilson, Alan A ; Rusjan, Pablo M ; Sailasuta, Napapon ; Mizrahi, Romina</creatorcontrib><description>Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molecular mechanisms underlying this interaction are not yet understood. To date, no study has investigated this link in vivo in the human brain. We conducted the first in vivo study linking translocator protein 18 kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [
F]FEPPA, and 3T proton magnetic resonance spectroscopy (
H MRS). The omnibus model (including TSPO genotype as covariate) was significant (F
= 10.01, p < 0.001), with a significant group interaction (t = -2.10, p = 0.04), suggesting a different relation between [
F]FEPPA V
and glutathione in each clinical group. In healthy volunteers, but not in individuals at clinical high risk for psychosis, we found a significant negative association between glutathione levels and [
F]FEPPA V
(r = -0.60, p = 0.006). We observed no significant group differences with respect to [
F]FEPPA V
or glutathione levels. These findings suggest an abnormal interaction between TSPO expression and redox status in the clinical high risk states for psychosis.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-018-0061-5</identifier><identifier>PMID: 29748630</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Anilides ; Antioxidants ; Antipsychotics ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Female ; Genotypes ; Glutathione ; Glutathione - metabolism ; Humans ; Immune response ; Magnetic resonance spectroscopy ; Male ; Mental disorders ; Molecular chains ; Molecular modelling ; NMR ; Nuclear magnetic resonance ; Oxidation-Reduction ; Oxidative stress ; Positron emission tomography ; Prefrontal cortex ; Prodromal Symptoms ; Proton magnetic resonance ; Proton Magnetic Resonance Spectroscopy ; Psychosis ; Psychotic Disorders - diagnostic imaging ; Psychotic Disorders - metabolism ; Pyridines ; Radiopharmaceuticals ; Receptors, GABA - metabolism ; Risk ; Schizophrenia ; Young Adult</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1700-1705</ispartof><rights>Copyright Nature Publishing Group Jul 2018</rights><rights>American College of Neuropsychopharmacology 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-9f37198942ff319921689e9bfe6d7d8cd66854edb5460a0324617dc7aaddf3f23</citedby><cites>FETCH-LOGICAL-c493t-9f37198942ff319921689e9bfe6d7d8cd66854edb5460a0324617dc7aaddf3f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006145/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006145/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29748630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hafizi, Sina</creatorcontrib><creatorcontrib>Da Silva, Tania</creatorcontrib><creatorcontrib>Meyer, Jeffrey H</creatorcontrib><creatorcontrib>Kiang, Michael</creatorcontrib><creatorcontrib>Houle, Sylvain</creatorcontrib><creatorcontrib>Remington, Gary</creatorcontrib><creatorcontrib>Prce, Ivana</creatorcontrib><creatorcontrib>Wilson, Alan A</creatorcontrib><creatorcontrib>Rusjan, Pablo M</creatorcontrib><creatorcontrib>Sailasuta, Napapon</creatorcontrib><creatorcontrib>Mizrahi, Romina</creatorcontrib><title>Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molecular mechanisms underlying this interaction are not yet understood. To date, no study has investigated this link in vivo in the human brain. We conducted the first in vivo study linking translocator protein 18 kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [
F]FEPPA, and 3T proton magnetic resonance spectroscopy (
H MRS). The omnibus model (including TSPO genotype as covariate) was significant (F
= 10.01, p < 0.001), with a significant group interaction (t = -2.10, p = 0.04), suggesting a different relation between [
F]FEPPA V
and glutathione in each clinical group. In healthy volunteers, but not in individuals at clinical high risk for psychosis, we found a significant negative association between glutathione levels and [
F]FEPPA V
(r = -0.60, p = 0.006). We observed no significant group differences with respect to [
F]FEPPA V
or glutathione levels. These findings suggest an abnormal interaction between TSPO expression and redox status in the clinical high risk states for psychosis.</description><subject>Anilides</subject><subject>Antioxidants</subject><subject>Antipsychotics</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Female</subject><subject>Genotypes</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Immune response</subject><subject>Magnetic resonance spectroscopy</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Molecular chains</subject><subject>Molecular modelling</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Positron emission tomography</subject><subject>Prefrontal cortex</subject><subject>Prodromal Symptoms</subject><subject>Proton magnetic resonance</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Psychosis</subject><subject>Psychotic Disorders - diagnostic imaging</subject><subject>Psychotic Disorders - metabolism</subject><subject>Pyridines</subject><subject>Radiopharmaceuticals</subject><subject>Receptors, GABA - metabolism</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Young Adult</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU9PFTEUxRsjkQf6AdyYJm7cVNppp9O6MDEElAQDkWfCrunrH15hpn20M-D79nbykKiru-i5557THwBvCf5IMBVHhREqOMJEIIw5Qe0LsCAdw4hTdv0SLLCQFBFKr_fBQSm3GJO24-IV2G9kxwSneAHKWRxd1mYMKcKVGx-di3B5dXmBNIxuyikMwxQdHHS-cxnpaGF2Nv2CZdTjVGCI0PQhBqN7uA43a5hDuYM-ZbgpW7NOJZRPUMPLkyX6_uOqbk12-xrsed0X9-ZpHoKfpyfL42_o_OLr2fGXc2SYpCOSnnZECska7ymRsiFcSCdX3nHbWWEs56Jlzq5axrHGtGGcdNZ0WlvrqW_oIfi8891Mq8FZ4-KYda82OdQ2W5V0UP--xLBWN-lB8fk3WVsNPjwZ5HQ_uTKqIRTj-l5Hl6aimgqhmVPMt97_J71NU461XlXxCoJhTKuK7FQmp1Ky889hCFYzUrVDqipSNYdQc4h3f7d43vjDkP4GDhedkw</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Hafizi, Sina</creator><creator>Da Silva, Tania</creator><creator>Meyer, Jeffrey H</creator><creator>Kiang, Michael</creator><creator>Houle, Sylvain</creator><creator>Remington, Gary</creator><creator>Prce, Ivana</creator><creator>Wilson, Alan A</creator><creator>Rusjan, Pablo M</creator><creator>Sailasuta, Napapon</creator><creator>Mizrahi, Romina</creator><general>Nature Publishing Group</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study</title><author>Hafizi, Sina ; Da Silva, Tania ; Meyer, Jeffrey H ; Kiang, Michael ; Houle, Sylvain ; Remington, Gary ; Prce, Ivana ; Wilson, Alan A ; Rusjan, Pablo M ; Sailasuta, Napapon ; Mizrahi, Romina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-9f37198942ff319921689e9bfe6d7d8cd66854edb5460a0324617dc7aaddf3f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anilides</topic><topic>Antioxidants</topic><topic>Antipsychotics</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Female</topic><topic>Genotypes</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Immune response</topic><topic>Magnetic resonance spectroscopy</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Molecular chains</topic><topic>Molecular modelling</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Positron emission tomography</topic><topic>Prefrontal cortex</topic><topic>Prodromal Symptoms</topic><topic>Proton magnetic resonance</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>Psychosis</topic><topic>Psychotic Disorders - diagnostic imaging</topic><topic>Psychotic Disorders - metabolism</topic><topic>Pyridines</topic><topic>Radiopharmaceuticals</topic><topic>Receptors, GABA - metabolism</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hafizi, Sina</creatorcontrib><creatorcontrib>Da Silva, Tania</creatorcontrib><creatorcontrib>Meyer, Jeffrey H</creatorcontrib><creatorcontrib>Kiang, Michael</creatorcontrib><creatorcontrib>Houle, Sylvain</creatorcontrib><creatorcontrib>Remington, Gary</creatorcontrib><creatorcontrib>Prce, Ivana</creatorcontrib><creatorcontrib>Wilson, Alan A</creatorcontrib><creatorcontrib>Rusjan, Pablo M</creatorcontrib><creatorcontrib>Sailasuta, Napapon</creatorcontrib><creatorcontrib>Mizrahi, Romina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hafizi, Sina</au><au>Da Silva, Tania</au><au>Meyer, Jeffrey H</au><au>Kiang, Michael</au><au>Houle, Sylvain</au><au>Remington, Gary</au><au>Prce, Ivana</au><au>Wilson, Alan A</au><au>Rusjan, Pablo M</au><au>Sailasuta, Napapon</au><au>Mizrahi, Romina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>43</volume><issue>8</issue><spage>1700</spage><epage>1705</epage><pages>1700-1705</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><abstract>Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molecular mechanisms underlying this interaction are not yet understood. To date, no study has investigated this link in vivo in the human brain. We conducted the first in vivo study linking translocator protein 18 kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [
F]FEPPA, and 3T proton magnetic resonance spectroscopy (
H MRS). The omnibus model (including TSPO genotype as covariate) was significant (F
= 10.01, p < 0.001), with a significant group interaction (t = -2.10, p = 0.04), suggesting a different relation between [
F]FEPPA V
and glutathione in each clinical group. In healthy volunteers, but not in individuals at clinical high risk for psychosis, we found a significant negative association between glutathione levels and [
F]FEPPA V
(r = -0.60, p = 0.006). We observed no significant group differences with respect to [
F]FEPPA V
or glutathione levels. These findings suggest an abnormal interaction between TSPO expression and redox status in the clinical high risk states for psychosis.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>29748630</pmid><doi>10.1038/s41386-018-0061-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-133X |
| ispartof | Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1700-1705 |
| issn | 0893-133X 1740-634X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6006145 |
| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anilides Antioxidants Antipsychotics Brain Brain - diagnostic imaging Brain - metabolism Female Genotypes Glutathione Glutathione - metabolism Humans Immune response Magnetic resonance spectroscopy Male Mental disorders Molecular chains Molecular modelling NMR Nuclear magnetic resonance Oxidation-Reduction Oxidative stress Positron emission tomography Prefrontal cortex Prodromal Symptoms Proton magnetic resonance Proton Magnetic Resonance Spectroscopy Psychosis Psychotic Disorders - diagnostic imaging Psychotic Disorders - metabolism Pyridines Radiopharmaceuticals Receptors, GABA - metabolism Risk Schizophrenia Young Adult |
| title | Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T03%3A55%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interaction%20between%20TSPO-a%20neuroimmune%20marker-and%20redox%20status%20in%20clinical%20high%20risk%20for%20psychosis:%20a%20PET-MRS%20study&rft.jtitle=Neuropsychopharmacology%20(New%20York,%20N.Y.)&rft.au=Hafizi,%20Sina&rft.date=2018-07-01&rft.volume=43&rft.issue=8&rft.spage=1700&rft.epage=1705&rft.pages=1700-1705&rft.issn=0893-133X&rft.eissn=1740-634X&rft_id=info:doi/10.1038/s41386-018-0061-5&rft_dat=%3Cproquest_pubme%3E2038266852%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2060894003&rft_id=info:pmid/29748630&rfr_iscdi=true |