Population pharmacokinetics of voriconazole and CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients

Aims The aims of the present study were to characterize the pharmacokinetics of voriconazole in renal transplant recipients and to identify factors significantly affecting pharmacokinetic parameters. We also aimed to explore the optimal dosing regimens for patients who developed invasive fungal infe...

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Veröffentlicht in:	British journal of clinical pharmacology 2018-07, Vol.84 (7), p.1587-1597
Hauptverfasser:	Lin, Xiao‐bin, Li, Zi‐wei, Yan, Miao, Zhang, Bi‐kui, Liang, Wu, Wang, Feng, Xu, Ping, Xiang, Da‐xiong, Xie, Xu‐biao, Yu, Shao‐jie, Lan, Gong‐bin, Peng, Feng‐hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antifungal Agents - administration & dosage Antifungal Agents - adverse effects Antifungal Agents - pharmacokinetics Biological Availability Biological Variation, Population - physiology Body Weight CYP2C19 polymorphism Cytochrome P-450 CYP2C19 - genetics Cytochrome P-450 CYP2C19 - metabolism Dose-Response Relationship, Drug dosing simulation Female Genotype Graft Rejection - immunology Graft Rejection - prevention & control Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Intestinal Absorption Invasive Fungal Infections - drug therapy Invasive Fungal Infections - immunology Kidney Transplantation - adverse effects Male Middle Aged Models, Biological Original Polymorphism, Single Nucleotide population pharmacokinetics Postoperative Period Prospective Studies renal transplant recipients Time Factors Transplant Recipients voriconazole Voriconazole - administration & dosage Voriconazole - adverse effects Voriconazole - pharmacokinetics Young Adult
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