High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model

The GD2 ganglioside, which is abundant on the surface of neuroblastoma cells, is targeted by an FDA-approved therapeutic monoclonal antibody and is an attractive tumor-associated antigen for cellular immunotherapy. Chimeric antigen receptor (CAR)-modified T cells can have potent antitumor activity i...

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Veröffentlicht in:	Cancer immunology research 2018-01, Vol.6 (1), p.36-46
Hauptverfasser:	Richman, Sarah A, Nunez-Cruz, Selene, Moghimi, Babak, Li, Lucy Z, Gershenson, Zachary T, Mourelatos, Zissimos, Barrett, David M, Grupp, Stephan A, Milone, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD3 Complex - genetics Cell Line, Tumor Cell Proliferation Cytotoxicity, Immunologic Disease Models, Animal Encephalitis - diagnosis Encephalitis - etiology Gangliosides - immunology Gangliosides - metabolism Gene Order Genetic Vectors - genetics Humans Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Mice Neuroblastoma - complications Neuroblastoma - immunology Neuroblastoma - therapy Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism Xenograft Model Antitumor Assays
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