Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p/FUT2/β-catenin axis

Osteoarthritis (OA) is a chronic joint disease and hard to cure at present. Accumulating evidence suggests long noncoding RNA-HOTAIR (lncRNA-HOTAIR) plays important role in OA progression. However, the underlying molecular mechanism of HOTAIR in OA progression has not been well elucidated. In the pr...

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Veröffentlicht in:	Cell death & disease 2018-06, Vol.9 (7), p.711-12, Article 711
Hauptverfasser:	Hu, Jialei, Wang, Zi, Shan, Yujia, Pan, Yue, Ma, Jia, Jia, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 13/51 38/109 38/77 45/90 82/1 96/21 96/34 Adult Aged Antibodies Apoptosis Apoptosis - drug effects Apoptosis - genetics Arthritis Base Sequence beta Catenin - genetics beta Catenin - metabolism Biochemistry Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Biology Cell Culture Cell Proliferation - drug effects Chondrocytes Chondrocytes - metabolism Disease Progression Extracellular matrix Extracellular Matrix - metabolism Fucosyltransferases - genetics Fucosyltransferases - metabolism Galactoside 2-a-L-fucosyltransferase Galactoside 2-alpha-L-fucosyltransferase Gene Expression Regulation Humans Immunology Immunoprecipitation Interleukin-1beta - pharmacology Joint diseases Life Sciences MicroRNAs - genetics MicroRNAs - metabolism Non-coding RNA Osteoarthritis Osteoarthritis - genetics Osteoarthritis - pathology RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Wnt protein Wnt Signaling Pathway - drug effects β-Catenin
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