Comparative glycoproteomics of stem cells identifies new players in ricin toxicity

A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing inference of complex glycan structures and direct mapping of them to sites within the associated proteins at the proteome scale. Pinpointing glycoproteins The activity of more than half of h...

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Veröffentlicht in:	Nature (London) 2017-09, Vol.549 (7673), p.538-542
Hauptverfasser:	Stadlmann, Johannes, Taubenschmid, Jasmin, Wenzel, Daniel, Gattinger, Anna, Dürnberger, Gerhard, Dusberger, Frederico, Elling, Ulrich, Mach, Lukas, Mechtler, Karl, Penninger, Josef M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 631/1647/2067 631/80/458/1524 64/60 692/308/2171 82/56 82/58 Animals Binding sites Carbohydrates Chromatography Embryo cells Embryonic Stem Cells - chemistry Embryonic Stem Cells - drug effects Embryonic Stem Cells - enzymology Embryonic Stem Cells - metabolism Embryos Fucosyltransferases - genetics Genomes Glycan Glycopeptides Glycopeptides - analysis Glycopeptides - chemistry Glycopeptides - metabolism Glycoproteins Glycoproteins - analysis Glycoproteins - chemistry Glycoproteins - metabolism Glycosylation Health aspects Humanities and Social Sciences Humans letter Membrane Transport Proteins - genetics Mice Monosaccharide Transport Proteins multidisciplinary Mutation Peptides Post-translation Protein Processing, Post-Translational - genetics Proteins Proteome - analysis Proteome - chemistry Proteome - genetics Proteome - metabolism Proteomics Ricin Ricin - toxicity Science Stem cell transplantation Stem cells Sugar Toxicity
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