SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma

Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normall...

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Veröffentlicht in:	Oncotarget 2018-06, Vol.9 (42), p.26852-26867
Hauptverfasser:	Kaur, Gagandeep, Li, Caiyun Grace, Chantry, Andrew, Stayner, Cherie, Horsfield, Julia, Eccles, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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