ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling

Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing proovarian pathways, while RSPO1/WNT-β-catenin/FOXL2 signals control ovary development by inhibiting SRY-SOX9-FGF9. The molec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-05, Vol.115 (21), p.5474-5479
Hauptverfasser:	Harris, Abigail, Siggers, Pam, Corrochano, Silvia, Warr, Nick, Sagar, Danielle, Grimes, Daniel T., Suzuki, Makoto, Burdine, Rebecca D., Cong, Feng, Koo, Bon-Kyoung, Clevers, Hans, Stévant, Isabelle, Nef, Serge, Wells, Sara, Brauner, Raja, Rhouma, Bochra Ben, Belguith, Neïla, Eozenou, Caroline, Bignon-Topalovic, Joelle, Bashamboo, Anu, McElreavey, Ken, Greenfield, Andy
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adolescent Adult Animals Antagonism beta Catenin - antagonists & inhibitors beta Catenin - genetics beta Catenin - metabolism Biological Sciences Cell lines Cells Cells, Cultured Disorders of Sex Development - genetics Disorders of Sex Development - pathology Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Embryos Female Fetuses Fibroblast growth factor receptor 9 Gene Expression Regulation, Developmental Genetics Gonads - metabolism Gonads - pathology Human genetics Humans Life Sciences Male Mammals Medical disorders Mice Molecular interactions Mutation, Missense Pregnancy complications Sex Sex determination Sex Differentiation Sex reversal Signal transduction Signaling Sox9 protein SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Testis - metabolism Testis - pathology Thrombospondins - genetics Thrombospondins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology Wnt protein Wnt Proteins - antagonists & inhibitors Wnt Proteins - genetics Wnt Proteins - metabolism Young Adult Zebrafish β-Catenin
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