Global assessment of its network dynamics reveals that polo-like kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity

Polo-like kinase 1 (Plk1) is an essential protein kinase that promotes faithful mitotic progression in eukaryotes. The subcellular localization and substrate interactions of Plk1 are tightly controlled and require its binding to phosphorylated sequences. Here, to identify phosphorylation-dependent i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science signaling 2018-05, Vol.11 (530)
Hauptverfasser:	Kettenbach, Arminja N., Schlosser, Kate A., Lyons, Scott. P., Nasa, Isha, Gui, Jiang, Adamo, Mark E., Gerber, Scott A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!