Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions

Abstract The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate–ca...

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Veröffentlicht in:	Glycobiology (Oxford) 2018-07, Vol.28 (7), p.437-442
Hauptverfasser:	Sletmoen, Marit, Gerken, Thomas A, Stokke, Bjørn T, Burchell, Joy, Brewer, C Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - chemistry Antigens, Neoplasm - metabolism Carcinogenesis Humans Letter to Glycoforum Polysaccharides - chemistry Polysaccharides - metabolism
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Zusammenfassung:	Abstract The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate–carbohydrate interactions, CCIs) of Tn (Tn–Tn) and STn (STn–STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.
ISSN:	1460-2423 0959-6658 1460-2423
DOI:	10.1093/glycob/cwy032