Novel insights into Sabino1 and splashed white coat color patterns in horses
Summary Within the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.1...
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| Veröffentlicht in: | Animal genetics 2018-06, Vol.49 (3), p.249-253 |
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| creator | Druml, T. Grilz‐Seger, G. Neuditschko, M. Horna, M. Ricard, A. Pausch, H. Brem, G. |
| description | Summary
Within the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y), including a total of 899 horses originating from eight different breeds (Achal Theke, Purebred Arabian, Partbred Arabian, Anglo‐Arabian, Shagya Arabian, Haflinger, Lipizzan and Noriker). Based on the data we collected we were able to demonstrate that, besides Quarter horses, the PAX3C70Y allele is also present in Noriker (seven out of 189) and Lipizzan (three out of 329) horses. The SB1 allele was present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329). Furthermore, we examined the phenotypes of SB1‐ and PAX3C70Y‐carrier horses for their characteristic white spotting patterns. None of the SB1/sb1‐carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. From 10 heterozygous PAX3C70Y‐carrier horses, two had nearly a splashed white phenotype. The results of this large‐scale experiment on the genetic association of white spotting patterns in horses underline the influence of gene interactions and population differences on complex traits such as Sabino1 and splashed white. |
| doi_str_mv | 10.1111/age.12657 |
| format | Article |
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Within the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y), including a total of 899 horses originating from eight different breeds (Achal Theke, Purebred Arabian, Partbred Arabian, Anglo‐Arabian, Shagya Arabian, Haflinger, Lipizzan and Noriker). Based on the data we collected we were able to demonstrate that, besides Quarter horses, the PAX3C70Y allele is also present in Noriker (seven out of 189) and Lipizzan (three out of 329) horses. The SB1 allele was present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329). Furthermore, we examined the phenotypes of SB1‐ and PAX3C70Y‐carrier horses for their characteristic white spotting patterns. None of the SB1/sb1‐carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. From 10 heterozygous PAX3C70Y‐carrier horses, two had nearly a splashed white phenotype. The results of this large‐scale experiment on the genetic association of white spotting patterns in horses underline the influence of gene interactions and population differences on complex traits such as Sabino1 and splashed white.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/age.12657</identifier><identifier>PMID: 29635692</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alleles ; Animal genetics ; association ; Color ; Coloration ; gene interaction ; Genetics ; genome-wide association study ; Genomes ; Genotyping ; Haflinger ; hairs ; heterozygosity ; Horses ; KIT protein ; Life Sciences ; Lipizzaner ; Pax3 gene ; Pax3 protein ; phenotype ; Phenotypes ; purebreds ; Quarter Horse ; sabino ; Shagya Arabian ; Short Communication ; Short Communications ; single nucleotide polymorphism ; white spotting patterns</subject><ispartof>Animal genetics, 2018-06, Vol.49 (3), p.249-253</ispartof><rights>2018 The Authors. published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.</rights><rights>2018 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.</rights><rights>Copyright © 2018 Stichting International Foundation for Animal Genetics</rights><rights>Attribution - NonCommercial - NoDerivatives</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5107-d79c75e11c8cbe888719bbfc16b31da016ffa5773873dc2cc64caeb93eca0ed33</citedby><cites>FETCH-LOGICAL-c5107-d79c75e11c8cbe888719bbfc16b31da016ffa5773873dc2cc64caeb93eca0ed33</cites><orcidid>0000-0001-7824-701X ; 0000-0002-2113-5153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fage.12657$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fage.12657$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29635692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02621536$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Druml, T.</creatorcontrib><creatorcontrib>Grilz‐Seger, G.</creatorcontrib><creatorcontrib>Neuditschko, M.</creatorcontrib><creatorcontrib>Horna, M.</creatorcontrib><creatorcontrib>Ricard, A.</creatorcontrib><creatorcontrib>Pausch, H.</creatorcontrib><creatorcontrib>Brem, G.</creatorcontrib><title>Novel insights into Sabino1 and splashed white coat color patterns in horses</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>Summary
Within the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y), including a total of 899 horses originating from eight different breeds (Achal Theke, Purebred Arabian, Partbred Arabian, Anglo‐Arabian, Shagya Arabian, Haflinger, Lipizzan and Noriker). Based on the data we collected we were able to demonstrate that, besides Quarter horses, the PAX3C70Y allele is also present in Noriker (seven out of 189) and Lipizzan (three out of 329) horses. The SB1 allele was present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329). Furthermore, we examined the phenotypes of SB1‐ and PAX3C70Y‐carrier horses for their characteristic white spotting patterns. None of the SB1/sb1‐carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. From 10 heterozygous PAX3C70Y‐carrier horses, two had nearly a splashed white phenotype. The results of this large‐scale experiment on the genetic association of white spotting patterns in horses underline the influence of gene interactions and population differences on complex traits such as Sabino1 and splashed white.</description><subject>Alleles</subject><subject>Animal genetics</subject><subject>association</subject><subject>Color</subject><subject>Coloration</subject><subject>gene interaction</subject><subject>Genetics</subject><subject>genome-wide association study</subject><subject>Genomes</subject><subject>Genotyping</subject><subject>Haflinger</subject><subject>hairs</subject><subject>heterozygosity</subject><subject>Horses</subject><subject>KIT protein</subject><subject>Life Sciences</subject><subject>Lipizzaner</subject><subject>Pax3 gene</subject><subject>Pax3 protein</subject><subject>phenotype</subject><subject>Phenotypes</subject><subject>purebreds</subject><subject>Quarter Horse</subject><subject>sabino</subject><subject>Shagya Arabian</subject><subject>Short Communication</subject><subject>Short Communications</subject><subject>single nucleotide polymorphism</subject><subject>white spotting patterns</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkc1O3DAUha2qVRloF7wAitQNLAK-dmI7G6QR4qfSqF20XVuOczMxysSDnRnE2-MwgChSVS9sy_7u8fU5hBwCPYU0zswST4GJUn4gM-CizBkt2Ucyo0yovIJC7JH9GG8ppQokfCZ7rBK8FBWbkcUPv8U-c0N0y26MaTP67Jep3eAhM0OTxXVvYodNdt-5ETPrzZim3odsbcYRwzDVZJ0PEeMX8qk1fcSvz-sB-XN1-fviJl_8vP5-MV_ktgQq80ZWVpYIYJWtUSkloarr1oKoOTSGgmhbU0rJleSNZdaKwhqsK47WUGw4PyDnO931pl5hY3EYg-n1OriVCQ_aG6f_vhlcp5d-qwWlUHKRBE52At27spv5Qk9nyTk2kVtI7PHzY8HfbTCOeuWixb43A_pN1AwgOam4ov9HKSsoKODTF769Q2_9JgzJtUQVkouCve3TBh9jwPa1WaB6il6n6PVT9Ik9emvKK_mSdQLOdsC96_Hh30p6fn25k3wEh8e3WA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Druml, T.</creator><creator>Grilz‐Seger, G.</creator><creator>Neuditschko, M.</creator><creator>Horna, M.</creator><creator>Ricard, A.</creator><creator>Pausch, H.</creator><creator>Brem, G.</creator><general>Wiley Subscription Services, Inc</general><general>Wiley-Blackwell</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7824-701X</orcidid><orcidid>https://orcid.org/0000-0002-2113-5153</orcidid></search><sort><creationdate>201806</creationdate><title>Novel insights into Sabino1 and splashed white coat color patterns in horses</title><author>Druml, T. ; Grilz‐Seger, G. ; Neuditschko, M. ; Horna, M. ; Ricard, A. ; Pausch, H. ; Brem, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5107-d79c75e11c8cbe888719bbfc16b31da016ffa5773873dc2cc64caeb93eca0ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Animal genetics</topic><topic>association</topic><topic>Color</topic><topic>Coloration</topic><topic>gene interaction</topic><topic>Genetics</topic><topic>genome-wide association study</topic><topic>Genomes</topic><topic>Genotyping</topic><topic>Haflinger</topic><topic>hairs</topic><topic>heterozygosity</topic><topic>Horses</topic><topic>KIT protein</topic><topic>Life Sciences</topic><topic>Lipizzaner</topic><topic>Pax3 gene</topic><topic>Pax3 protein</topic><topic>phenotype</topic><topic>Phenotypes</topic><topic>purebreds</topic><topic>Quarter Horse</topic><topic>sabino</topic><topic>Shagya Arabian</topic><topic>Short Communication</topic><topic>Short Communications</topic><topic>single nucleotide polymorphism</topic><topic>white spotting patterns</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Druml, T.</creatorcontrib><creatorcontrib>Grilz‐Seger, G.</creatorcontrib><creatorcontrib>Neuditschko, M.</creatorcontrib><creatorcontrib>Horna, M.</creatorcontrib><creatorcontrib>Ricard, A.</creatorcontrib><creatorcontrib>Pausch, H.</creatorcontrib><creatorcontrib>Brem, G.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Druml, T.</au><au>Grilz‐Seger, G.</au><au>Neuditschko, M.</au><au>Horna, M.</au><au>Ricard, A.</au><au>Pausch, H.</au><au>Brem, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel insights into Sabino1 and splashed white coat color patterns in horses</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2018-06</date><risdate>2018</risdate><volume>49</volume><issue>3</issue><spage>249</spage><epage>253</epage><pages>249-253</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><abstract>Summary
Within the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y), including a total of 899 horses originating from eight different breeds (Achal Theke, Purebred Arabian, Partbred Arabian, Anglo‐Arabian, Shagya Arabian, Haflinger, Lipizzan and Noriker). Based on the data we collected we were able to demonstrate that, besides Quarter horses, the PAX3C70Y allele is also present in Noriker (seven out of 189) and Lipizzan (three out of 329) horses. The SB1 allele was present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329). Furthermore, we examined the phenotypes of SB1‐ and PAX3C70Y‐carrier horses for their characteristic white spotting patterns. None of the SB1/sb1‐carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. From 10 heterozygous PAX3C70Y‐carrier horses, two had nearly a splashed white phenotype. The results of this large‐scale experiment on the genetic association of white spotting patterns in horses underline the influence of gene interactions and population differences on complex traits such as Sabino1 and splashed white.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29635692</pmid><doi>10.1111/age.12657</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7824-701X</orcidid><orcidid>https://orcid.org/0000-0002-2113-5153</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Animal genetics, 2018-06, Vol.49 (3), p.249-253 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles Animal genetics association Color Coloration gene interaction Genetics genome-wide association study Genomes Genotyping Haflinger hairs heterozygosity Horses KIT protein Life Sciences Lipizzaner Pax3 gene Pax3 protein phenotype Phenotypes purebreds Quarter Horse sabino Shagya Arabian Short Communication Short Communications single nucleotide polymorphism white spotting patterns |
| title | Novel insights into Sabino1 and splashed white coat color patterns in horses |
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