miR‐542‐3p prevents ovariectomy‐induced osteoporosis in rats via targeting SFRP1

Secreted frizzled‐related protein‐1 (SFRP1) is a negative regulatory molecule of the WNT signaling pathway and serves as a therapeutic target for bone formation in osteoporosis. In this study, we first established an ovariectomized (OVX) rat model to simulate postmenopausal osteoporosis and found si...

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Veröffentlicht in:	Journal of cellular physiology 2018-09, Vol.233 (9), p.6798-6806
Hauptverfasser:	Zhang, Xiguang, Zhu, Yun, Zhang, Chuanlin, Liu, Jianping, Sun, Tianming, Li, Dan, Na, Qiang, Xian, Cory J., Wang, Liping, Teng, Zhaowei
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Animals Binding sites Binding Sites - physiology Biocompatibility Biomedical materials Bone growth Cell Differentiation - physiology Cell Line Computer simulation Differentiation Female Frizzled protein Frizzled-related protein 1 Gene expression Gene sequencing HEK293 Cells Humans Intercellular Signaling Peptides and Proteins - metabolism Membrane Proteins - metabolism Mesenchymal Stem Cells - metabolism Mesenchyme MicroRNAs - metabolism miRNA Molecular chains mRNA Original Original s Osteoblastogenesis Osteoblasts - metabolism Osteogenesis Osteoporosis Osteoporosis - metabolism Ovariectomy Ovariectomy - methods Post-menopause Proteins Rats Rats, Sprague-Dawley Ribonucleic acid RNA RNA, Messenger - metabolism SFRP1 Signal transduction Signal Transduction - physiology Stem cell transplantation Stem cells Therapeutic applications Wnt protein
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