GSK-3 promotes S-phase entry and progression in C. elegans germline stem cells to maintain tissue output

Adult germline stem cells (GSCs) and mouse embryonic stem cells (mESCs) exhibit a non-canonical cell cycle structure with an abbreviated G1 phase and phase-independent expression of Cdk2 and cyclin E. Mechanisms that promote the abbreviated cell cycle remain unknown, as do the consequences of not ma...

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Veröffentlicht in:	Development (Cambridge) 2018-05, Vol.145 (10), p.dev161042-dev161042
Hauptverfasser:	Furuta, Tokiko, Joo, Hyoe-Jin, Trimmer, Kenneth A, Chen, Shin-Yu, Arur, Swathi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell cycle Cell Differentiation - genetics Cell proliferation Cell Proliferation - genetics Cyclin E Cyclin E - biosynthesis Cyclin-dependent kinase Cyclin-dependent kinase 2 Cyclin-Dependent Kinase 2 - biosynthesis Cyclin-Dependent Kinase 2 - genetics Cyclin-dependent kinases Embryo cells G1 phase Gene regulation Germ Cells - cytology Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Notch protein Post-translation Receptors, Notch - metabolism RNA Interference RNA, Messenger - genetics RNA, Small Interfering - genetics S phase S Phase - physiology Signal Transduction - genetics Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells and Regeneration Transcription Transcription Factors - genetics Transcription, Genetic - genetics
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