URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion
Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expressio...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-10 |
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| creator | Zhong, Weifeng Zeng, Chuanrong Qu, Lijun Li, Yutong Zhou, Hongmei Zhen, Jianli Liu, Haiping Ye, Yunlin Pan, Bin Wu, Youke |
| description | Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP), compared with human prostate epithelial cell line (RWPE-1). Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited. Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells. Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells. Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer. |
| doi_str_mv | 10.1155/2018/4060728 |
| format | Article |
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However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP), compared with human prostate epithelial cell line (RWPE-1). Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited. Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells. Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells. Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/4060728</identifier><identifier>PMID: 29955600</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Animals ; Apoptosis ; Cancer ; Cell adhesion & migration ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement ; Cell Proliferation ; Colon ; Colon cancer ; Comparative analysis ; Cytokines ; Development and progression ; Disease ; Epithelial cells ; Gastric cancer ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; HBX protein ; Hepatitis ; Hepatitis B ; Hospitals ; Humans ; Hyperplasia ; Liver ; Liver cancer ; Lungs ; Male ; Medical research ; Metastasis ; Middle Aged ; mRNA ; Neoplasm Invasiveness ; Oncology, Experimental ; Pancreatic cancer ; Prostate cancer ; Prostatic Hyperplasia ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Proteins ; S phase ; siRNA ; Stomach ; Therapeutic applications ; Tissues ; Trans-Activators - physiology ; Tumor cell lines ; Tumors ; Up-Regulation ; Urology ; Viruses ; β-Catenin</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-10</ispartof><rights>Copyright © 2018 Bin Pan et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Bin Pan et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Bin Pan et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-abc9ffc8cd726e7e9ed049c4290340ea3e9baeaa62f45795b442d18bf8d7684c3</citedby><cites>FETCH-LOGICAL-c499t-abc9ffc8cd726e7e9ed049c4290340ea3e9baeaa62f45795b442d18bf8d7684c3</cites><orcidid>0000-0003-4650-176X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000846/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000846/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29955600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wong, Chun-Ming</contributor><contributor>Chun-Ming Wong</contributor><creatorcontrib>Zhong, Weifeng</creatorcontrib><creatorcontrib>Zeng, Chuanrong</creatorcontrib><creatorcontrib>Qu, Lijun</creatorcontrib><creatorcontrib>Li, Yutong</creatorcontrib><creatorcontrib>Zhou, Hongmei</creatorcontrib><creatorcontrib>Zhen, Jianli</creatorcontrib><creatorcontrib>Liu, Haiping</creatorcontrib><creatorcontrib>Ye, Yunlin</creatorcontrib><creatorcontrib>Pan, Bin</creatorcontrib><creatorcontrib>Wu, Youke</creatorcontrib><title>URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP), compared with human prostate epithelial cell line (RWPE-1). Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited. Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells. Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells. Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer.</description><subject>Aged</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Comparative analysis</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Epithelial cells</subject><subject>Gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>HBX protein</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>mRNA</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology, Experimental</subject><subject>Pancreatic cancer</subject><subject>Prostate cancer</subject><subject>Prostatic Hyperplasia</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Proteins</subject><subject>S phase</subject><subject>siRNA</subject><subject>Stomach</subject><subject>Therapeutic applications</subject><subject>Tissues</subject><subject>Trans-Activators - physiology</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Up-Regulation</subject><subject>Urology</subject><subject>Viruses</subject><subject>β-Catenin</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks9rFDEUx4MottTeepYBL4Jdm2TyY3IRyqK12KKU9hzeZF62KbOZmsxU_O_NsNutemoueUk-fJPv-4aQI0Y_MiblCaesORFUUc2bF2Sf10wsFBPs5a6u6z1ymPMdLaNhihr1muxxY6RUlO6TbzdXZ4xVV7iaehgxVz_SkMdSVUuIDlO1xL6fN_vgMcEYhnhcXYbVYwmxq87jA-SyekNeeegzHm7nA3Lz5fP18uvi4vvZ-fL0YuGEMeMCWme8d43rNFeo0WBHhXGCG1oLilCjaQEBFPdCaiNbIXjHmtY3nVaNcPUB-bTRvZ_aNXYO45igt_cprCH9tgME--9JDLd2NTxYNfdAqCLwfiuQhp8T5tGuQ3bFKEQcpmw5Vbypaa1NQd_9h94NU4rFXqEk14WR_IlaQY82RD-Ue90sak8VZ9oYoWWhjjeUKz3OCf3uyYzaOU47x2m3cRb87d82d_BjeAX4sAFuQ-zgV3imHBYGPTzRjKu6_JM_KomvRg</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Zhong, Weifeng</creator><creator>Zeng, Chuanrong</creator><creator>Qu, Lijun</creator><creator>Li, Yutong</creator><creator>Zhou, Hongmei</creator><creator>Zhen, Jianli</creator><creator>Liu, Haiping</creator><creator>Ye, Yunlin</creator><creator>Pan, Bin</creator><creator>Wu, Youke</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4650-176X</orcidid></search><sort><creationdate>20180101</creationdate><title>URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion</title><author>Zhong, Weifeng ; Zeng, Chuanrong ; Qu, Lijun ; Li, Yutong ; Zhou, Hongmei ; Zhen, Jianli ; Liu, Haiping ; Ye, Yunlin ; Pan, Bin ; Wu, Youke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-abc9ffc8cd726e7e9ed049c4290340ea3e9baeaa62f45795b442d18bf8d7684c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Comparative analysis</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Epithelial cells</topic><topic>Gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>HBX protein</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical research</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>mRNA</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology, Experimental</topic><topic>Pancreatic cancer</topic><topic>Prostate cancer</topic><topic>Prostatic Hyperplasia</topic><topic>Prostatic Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Weifeng</au><au>Zeng, Chuanrong</au><au>Qu, Lijun</au><au>Li, Yutong</au><au>Zhou, Hongmei</au><au>Zhen, Jianli</au><au>Liu, Haiping</au><au>Ye, Yunlin</au><au>Pan, Bin</au><au>Wu, Youke</au><au>Wong, Chun-Ming</au><au>Chun-Ming Wong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP), compared with human prostate epithelial cell line (RWPE-1). Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited. Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells. Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells. Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29955600</pmid><doi>10.1155/2018/4060728</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4650-176X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Animals Apoptosis Cancer Cell adhesion & migration Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Colon Colon cancer Comparative analysis Cytokines Development and progression Disease Epithelial cells Gastric cancer Gene Expression Regulation, Neoplastic Gene Knockdown Techniques HBX protein Hepatitis Hepatitis B Hospitals Humans Hyperplasia Liver Liver cancer Lungs Male Medical research Metastasis Middle Aged mRNA Neoplasm Invasiveness Oncology, Experimental Pancreatic cancer Prostate cancer Prostatic Hyperplasia Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteins S phase siRNA Stomach Therapeutic applications Tissues Trans-Activators - physiology Tumor cell lines Tumors Up-Regulation Urology Viruses β-Catenin |
| title | URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion |
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