A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell...
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| Veröffentlicht in: | Scientific reports 2018-06, Vol.8 (1), p.8972-8, Article 8972 |
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| creator | Valton, Julien Guyot, Valerie Boldajipour, Bijan Sommer, Cesar Pertel, Thomas Juillerat, Alexandre Duclert, Aymeric Sasu, Barbra Johnson Duchateau, Philippe Poirot, Laurent |
| description | CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell detection, purification and on-demand depletion by the FDA-approved antibody Rituximab. This novel architecture has the potential to streamline the manufacturing of CAR T-cells, allow their tracking and improve their overall safety. |
| doi_str_mv | 10.1038/s41598-018-27264-w |
| format | Article |
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| subjects | 13/107 13/109 13/31 13/44 42 59 59/5 631/67 631/67/1059/2325 64 64/60 82 Chimeric antigen receptors Humanities and Social Sciences Immunotherapy Lymphocytes T Monoclonal antibodies multidisciplinary Purification Rituximab Science Science (multidisciplinary) T cell receptors |
| title | A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies |
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