The Platelet Lifeline to Cancer: Challenges and Opportunities
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated w...
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| Veröffentlicht in: | Cancer cell 2018-06, Vol.33 (6), p.965-983 |
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| creator | Haemmerle, Monika Stone, Rebecca L. Menter, David G. Afshar-Kharghan, Vahid Sood, Anil K. |
| description | Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment. |
| doi_str_mv | 10.1016/j.ccell.2018.03.002 |
| format | Article |
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Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.</description><identifier>ISSN: 1535-6108</identifier><identifier>EISSN: 1878-3686</identifier><identifier>DOI: 10.1016/j.ccell.2018.03.002</identifier><identifier>PMID: 29657130</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; anti-platelet therapy ; aspirin ; biomarker ; Blood Platelets - metabolism ; Blood Platelets - physiology ; cancer ; cancer therapy ; Cell-Derived Microparticles - metabolism ; Disease Progression ; Exosomes - metabolism ; Humans ; metastasis ; microparticles ; Neoplasm Metastasis ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplasms - physiopathology ; platelets ; thrombocytosis ; Thrombocytosis - physiopathology ; tumor angiogenesis ; Tumor Burden</subject><ispartof>Cancer cell, 2018-06, Vol.33 (6), p.965-983</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-e5ee09f551ac94b6a1cab581e3cd1f32049f261b0b64839c1eaee0549e0a04803</citedby><cites>FETCH-LOGICAL-c575t-e5ee09f551ac94b6a1cab581e3cd1f32049f261b0b64839c1eaee0549e0a04803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1535610818300709$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29657130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haemmerle, Monika</creatorcontrib><creatorcontrib>Stone, Rebecca L.</creatorcontrib><creatorcontrib>Menter, David G.</creatorcontrib><creatorcontrib>Afshar-Kharghan, Vahid</creatorcontrib><creatorcontrib>Sood, Anil K.</creatorcontrib><title>The Platelet Lifeline to Cancer: Challenges and Opportunities</title><title>Cancer cell</title><addtitle>Cancer Cell</addtitle><description>Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.</description><subject>Animals</subject><subject>anti-platelet therapy</subject><subject>aspirin</subject><subject>biomarker</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Platelets - physiology</subject><subject>cancer</subject><subject>cancer therapy</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Disease Progression</subject><subject>Exosomes - metabolism</subject><subject>Humans</subject><subject>metastasis</subject><subject>microparticles</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - physiopathology</subject><subject>platelets</subject><subject>thrombocytosis</subject><subject>Thrombocytosis - physiopathology</subject><subject>tumor angiogenesis</subject><subject>Tumor Burden</subject><issn>1535-6108</issn><issn>1878-3686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P4zAQhi3Eiq_lFyChHLkkjOM4sZFAQhXsrlSpe2DPluNMqCs3KbZbiX-PSwuCy55mpHk_Rg8hFxQKCrS-XhTGoHNFCVQUwAqA8oCcUNGInNWiPkw7ZzyvKYhjchrCApKLNvKIHJey5g1lcEJun-aY_XU6osOYTW2Pzg6YxTGb6MGgv8kmc-0cDs8YMj102Wy1Gn1cDzZaDD_Jj167gOf7eUb-PT48TX7n09mvP5P7aW54w2OOHBFkzznVRlZtranRLRcUmeloz0qoZF_WtIW2rgSThqJOBl5JBA2VAHZG7na5q3W7xM7gEL12auXtUvtXNWqrvl8GO1fP40ZxKRsOLAVc7QP8-LLGENXShi09PeC4DqqEkjdSlHIrZTup8WMIHvvPGgpqC14t1Dt4tQWvgKkEPrkuv3746fkgnQS3OwEmThuLXgVjMSHurEcTVTfa_xa8AbQXlak</recordid><startdate>20180611</startdate><enddate>20180611</enddate><creator>Haemmerle, Monika</creator><creator>Stone, Rebecca L.</creator><creator>Menter, David G.</creator><creator>Afshar-Kharghan, Vahid</creator><creator>Sood, Anil K.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180611</creationdate><title>The Platelet Lifeline to Cancer: Challenges and Opportunities</title><author>Haemmerle, Monika ; Stone, Rebecca L. ; Menter, David G. ; Afshar-Kharghan, Vahid ; Sood, Anil K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-e5ee09f551ac94b6a1cab581e3cd1f32049f261b0b64839c1eaee0549e0a04803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>anti-platelet therapy</topic><topic>aspirin</topic><topic>biomarker</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Platelets - physiology</topic><topic>cancer</topic><topic>cancer therapy</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Disease Progression</topic><topic>Exosomes - metabolism</topic><topic>Humans</topic><topic>metastasis</topic><topic>microparticles</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - physiopathology</topic><topic>platelets</topic><topic>thrombocytosis</topic><topic>Thrombocytosis - physiopathology</topic><topic>tumor angiogenesis</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haemmerle, Monika</creatorcontrib><creatorcontrib>Stone, Rebecca L.</creatorcontrib><creatorcontrib>Menter, David G.</creatorcontrib><creatorcontrib>Afshar-Kharghan, Vahid</creatorcontrib><creatorcontrib>Sood, Anil K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haemmerle, Monika</au><au>Stone, Rebecca L.</au><au>Menter, David G.</au><au>Afshar-Kharghan, Vahid</au><au>Sood, Anil K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Platelet Lifeline to Cancer: Challenges and Opportunities</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2018-06-11</date><risdate>2018</risdate><volume>33</volume><issue>6</issue><spage>965</spage><epage>983</epage><pages>965-983</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29657130</pmid><doi>10.1016/j.ccell.2018.03.002</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals anti-platelet therapy aspirin biomarker Blood Platelets - metabolism Blood Platelets - physiology cancer cancer therapy Cell-Derived Microparticles - metabolism Disease Progression Exosomes - metabolism Humans metastasis microparticles Neoplasm Metastasis Neoplasms - metabolism Neoplasms - pathology Neoplasms - physiopathology platelets thrombocytosis Thrombocytosis - physiopathology tumor angiogenesis Tumor Burden |
| title | The Platelet Lifeline to Cancer: Challenges and Opportunities |
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