Gβγ subunit activation promotes dopamine efflux through the dopamine transporter

The dopamine transporter (DAT) is an important regulator of brain dopamine (DA) homeostasis, controlling the intensity and duration of DA signaling. DAT is the target for psychostimulants—like cocaine and amphetamine—and plays an important role in neuropsychiatric disorders, including attention-defi...

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Veröffentlicht in:	Molecular psychiatry 2017-12, Vol.22 (12), p.1673-1679
Hauptverfasser:	Garcia-Olivares, J, Baust, T, Harris, S, Hamilton, P, Galli, A, Amara, S G, Torres, G E
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/95 631/378 631/443 82 82/29 96 96/106 Acetylcholine receptors (muscarinic) Amphetamines Animals Attention deficit hyperactivity disorder Behavioral Sciences Binding sites Binding, Competitive Biological Psychology Brain - metabolism Cell culture Cells, Cultured Cocaine Cricetulus Dopamine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine receptors Dopamine transporter Dopaminergic Neurons - metabolism Drug addiction Female G protein-coupled receptors GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - metabolism Homeostasis Humans Hyperactivity immediate-communication Localization Medicine Medicine & Public Health Membrane Potentials - drug effects Membrane Potentials - physiology Mental disorders Neurosciences Peptides Pharmacotherapy Protein interaction Proteins Psychiatry Rats, Sprague-Dawley Receptor, Muscarinic M5 - metabolism
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