Conservation of Specificity in Two Low-Specificity Proteins

Many regulatory proteins bind peptide regions of target proteins and modulate their activity. Such regulatory proteins can often interact with highly diverse target peptides. In many instances, it is not known if the peptide-binding interface discriminates targets in a biological context, or whether...

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Veröffentlicht in:	Biochemistry (Easton) 2018-02, Vol.57 (5), p.684-695
Hauptverfasser:	Wheeler, Lucas C, Anderson, Jeremy A, Morrison, Anneliese J, Wong, Caitlyn E, Harms, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals binding properties Binding Sites Calcium Signaling calorimetry Calorimetry - methods Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Conserved Sequence Evolution, Molecular Gene Duplication Humans Hydrophobic and Hydrophilic Interactions mutation Mutation, Missense Peptide Library peptides Peptides - metabolism Phylogeny Recombinant Proteins - metabolism regulatory proteins S100 Calcium Binding Protein A6 - chemistry S100 Calcium Binding Protein A6 - genetics S100 Calcium Binding Protein A6 - metabolism S100 Proteins - chemistry S100 Proteins - genetics S100 Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity titration Vertebrates - genetics
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