Aptamer-Mediated Delivery and Cell-Targeting Aptamers: Room for Improvement

Targeting cells with aptamers for the delivery of therapeutic cargoes, in particular oligonucleotides, represents one of the most exciting applications of the aptamer field. Perhaps nowhere has there been more excitement in the field than around the targeted delivery of siRNA or miRNA. However, when...

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Veröffentlicht in:	Nucleic acid therapeutics 2018-06, Vol.28 (3), p.194-199
Hauptverfasser:	Yan, Amy C., Levy, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Biochemistry Biological Transport Cancer therapies Clinical trials Clinical Trials as Topic Cytoplasm Cytosol - metabolism Drugs Endosomes - metabolism FDA approval Gene Transfer Techniques Genetic Therapy - methods Humans Immunoglobulins Issues in Development Laboratories Ligands Macular degeneration Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology Macular Degeneration - therapy miRNA Molecular chains Nanoparticles Oligonucleotides Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Polyethylene glycol Proteins RNA, Small Interfering - genetics RNA, Small Interfering - metabolism SELEX Aptamer Technique siRNA Structure-Activity Relationship Vascular endothelial growth factor
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