Effects of an artificial placenta on brain development and injury in premature lambs
We evaluated whether brain development continues and brain injury is prevented during Artificial Placenta (AP) support utilizing extracorporeal life support (ECLS). Lambs at EGA 118days (term=145; n=4) were placed on AP support (venovenous ECLS with jugular drainage and umbilical vein reinfusion) fo...
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| Veröffentlicht in: | Journal of pediatric surgery 2018-06, Vol.53 (6), p.1234-1239 |
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| creator | Church, Joseph T. Werner, Nicole L. Coughlin, Meghan A. Menzel-Smith, Julia Najjar, Mary Carr, Benjamin D. Parmar, Hemant Neil, Jeff Alexopoulos, Dimitrios Perez-Torres, Carlos Ge, Xia Beeman, Scott C. Garbow, Joel R. Mychaliska, George B. |
| description | We evaluated whether brain development continues and brain injury is prevented during Artificial Placenta (AP) support utilizing extracorporeal life support (ECLS).
Lambs at EGA 118days (term=145; n=4) were placed on AP support (venovenous ECLS with jugular drainage and umbilical vein reinfusion) for 7days and sacrificed. Early (EGA 118; n=4) and late (EGA 127; n=4) mechanical ventilation (MV) lambs underwent conventional MV for up to 48h and were sacrificed, and early (n=5) and late (n=5) tissue control (TC) lambs were sacrificed at delivery. Brains were harvested, formalin-fixed, rehydrated, and studied by magnetic resonance imaging (MRI). The gyrification index (GI), a measure of cerebral folding complexity, was calculated for each brain. Diffusion-weighted imaging was used to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple structures to assess white matter (WM) integrity.
No intracranial hemorrhage was observed. GI was similar between AP and TC groups. ADC and FA did not differ between AP and late TC groups in any structure. Compared to late MV brains, AP brains demonstrated significantly higher ADC (0.45±0.08 vs. 0.27±0.11, p=0.02) and FA (0.61±0.04 vs. 0.44±0.05; p=0.006) in the cerebral peduncles.
After 7days of AP support, WM integrity is preserved relative to mechanical ventilation.
Research study. |
| doi_str_mv | 10.1016/j.jpedsurg.2018.02.091 |
| format | Article |
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Lambs at EGA 118days (term=145; n=4) were placed on AP support (venovenous ECLS with jugular drainage and umbilical vein reinfusion) for 7days and sacrificed. Early (EGA 118; n=4) and late (EGA 127; n=4) mechanical ventilation (MV) lambs underwent conventional MV for up to 48h and were sacrificed, and early (n=5) and late (n=5) tissue control (TC) lambs were sacrificed at delivery. Brains were harvested, formalin-fixed, rehydrated, and studied by magnetic resonance imaging (MRI). The gyrification index (GI), a measure of cerebral folding complexity, was calculated for each brain. Diffusion-weighted imaging was used to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple structures to assess white matter (WM) integrity.
No intracranial hemorrhage was observed. GI was similar between AP and TC groups. ADC and FA did not differ between AP and late TC groups in any structure. Compared to late MV brains, AP brains demonstrated significantly higher ADC (0.45±0.08 vs. 0.27±0.11, p=0.02) and FA (0.61±0.04 vs. 0.44±0.05; p=0.006) in the cerebral peduncles.
After 7days of AP support, WM integrity is preserved relative to mechanical ventilation.
Research study.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2018.02.091</identifier><identifier>PMID: 29605267</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Anisotropy ; Artificial Organs ; Artificial placenta ; Brain - diagnostic imaging ; Brain - growth & development ; Brain development ; Brain Injuries - diagnostic imaging ; Brain Injuries - prevention & control ; Disease Models, Animal ; Extracorporeal life support ; Extracorporeal Membrane Oxygenation - methods ; Female ; Humans ; Infant, Premature - physiology ; Magnetic Resonance Imaging ; Placenta ; Pregnancy ; Prematurity ; Respiration, Artificial ; Sheep ; White matter injury</subject><ispartof>Journal of pediatric surgery, 2018-06, Vol.53 (6), p.1234-1239</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-b7f5fb2172bc7ae35cd05c28d5923455be6e55324cfb731871326e059979ded23</citedby><cites>FETCH-LOGICAL-c537t-b7f5fb2172bc7ae35cd05c28d5923455be6e55324cfb731871326e059979ded23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022346818301763$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29605267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Church, Joseph T.</creatorcontrib><creatorcontrib>Werner, Nicole L.</creatorcontrib><creatorcontrib>Coughlin, Meghan A.</creatorcontrib><creatorcontrib>Menzel-Smith, Julia</creatorcontrib><creatorcontrib>Najjar, Mary</creatorcontrib><creatorcontrib>Carr, Benjamin D.</creatorcontrib><creatorcontrib>Parmar, Hemant</creatorcontrib><creatorcontrib>Neil, Jeff</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Perez-Torres, Carlos</creatorcontrib><creatorcontrib>Ge, Xia</creatorcontrib><creatorcontrib>Beeman, Scott C.</creatorcontrib><creatorcontrib>Garbow, Joel R.</creatorcontrib><creatorcontrib>Mychaliska, George B.</creatorcontrib><title>Effects of an artificial placenta on brain development and injury in premature lambs</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>We evaluated whether brain development continues and brain injury is prevented during Artificial Placenta (AP) support utilizing extracorporeal life support (ECLS).
Lambs at EGA 118days (term=145; n=4) were placed on AP support (venovenous ECLS with jugular drainage and umbilical vein reinfusion) for 7days and sacrificed. Early (EGA 118; n=4) and late (EGA 127; n=4) mechanical ventilation (MV) lambs underwent conventional MV for up to 48h and were sacrificed, and early (n=5) and late (n=5) tissue control (TC) lambs were sacrificed at delivery. Brains were harvested, formalin-fixed, rehydrated, and studied by magnetic resonance imaging (MRI). The gyrification index (GI), a measure of cerebral folding complexity, was calculated for each brain. Diffusion-weighted imaging was used to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple structures to assess white matter (WM) integrity.
No intracranial hemorrhage was observed. GI was similar between AP and TC groups. ADC and FA did not differ between AP and late TC groups in any structure. Compared to late MV brains, AP brains demonstrated significantly higher ADC (0.45±0.08 vs. 0.27±0.11, p=0.02) and FA (0.61±0.04 vs. 0.44±0.05; p=0.006) in the cerebral peduncles.
After 7days of AP support, WM integrity is preserved relative to mechanical ventilation.
Research study.</description><subject>Animals</subject><subject>Anisotropy</subject><subject>Artificial Organs</subject><subject>Artificial placenta</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - growth & development</subject><subject>Brain development</subject><subject>Brain Injuries - diagnostic imaging</subject><subject>Brain Injuries - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Extracorporeal life support</subject><subject>Extracorporeal Membrane Oxygenation - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Premature - physiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Prematurity</subject><subject>Respiration, Artificial</subject><subject>Sheep</subject><subject>White matter injury</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaTab_oWgYy92RpJl2ZfSEtKkEOglOQtZGqUy_qpkL-TfV8smoT31NDB65p1BDyGXDEoGrL7qy35Bl7b4VHJgTQm8hJa9IzsmBSskCPWe7AA4L0RVN2fkPKUeILeBfSRnvK1B8lrtyMON92jXRGdPzURNXIMPNpiBLoOxOK2GzhPtogkTdXjAYV7G3M2so2Hqt_icC10ijmbdItLBjF26IB-8GRJ-eql78vj95uH6rrj_efvj-tt9YaVQa9EpL33HmeKdVQaFtA6k5Y2TLReVlB3WKKXglfWdEqxRTPAaQbatah06Lvbkyyl32boR3fHcaAa9xDCa-KxnE_S_L1P4pZ_mg84RlcjRe_L5JSDOvzdMqx5DsjgMZsJ5S5oDh6ZpKlVltD6hNs4pRfRvaxjooxLd61cl-qhEA9dZSR68_PvIt7FXBxn4egIwf9UhYNTJBpwsuhCzGu3m8L8dfwB5w6JV</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Church, Joseph T.</creator><creator>Werner, Nicole L.</creator><creator>Coughlin, Meghan A.</creator><creator>Menzel-Smith, Julia</creator><creator>Najjar, Mary</creator><creator>Carr, Benjamin D.</creator><creator>Parmar, Hemant</creator><creator>Neil, Jeff</creator><creator>Alexopoulos, Dimitrios</creator><creator>Perez-Torres, Carlos</creator><creator>Ge, Xia</creator><creator>Beeman, Scott C.</creator><creator>Garbow, Joel R.</creator><creator>Mychaliska, George B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Effects of an artificial placenta on brain development and injury in premature lambs</title><author>Church, Joseph T. ; Werner, Nicole L. ; Coughlin, Meghan A. ; Menzel-Smith, Julia ; Najjar, Mary ; Carr, Benjamin D. ; Parmar, Hemant ; Neil, Jeff ; Alexopoulos, Dimitrios ; Perez-Torres, Carlos ; Ge, Xia ; Beeman, Scott C. ; Garbow, Joel R. ; Mychaliska, George B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-b7f5fb2172bc7ae35cd05c28d5923455be6e55324cfb731871326e059979ded23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anisotropy</topic><topic>Artificial Organs</topic><topic>Artificial placenta</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - growth & development</topic><topic>Brain development</topic><topic>Brain Injuries - diagnostic imaging</topic><topic>Brain Injuries - prevention & control</topic><topic>Disease Models, Animal</topic><topic>Extracorporeal life support</topic><topic>Extracorporeal Membrane Oxygenation - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Premature - physiology</topic><topic>Magnetic Resonance Imaging</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Prematurity</topic><topic>Respiration, Artificial</topic><topic>Sheep</topic><topic>White matter injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Church, Joseph T.</creatorcontrib><creatorcontrib>Werner, Nicole L.</creatorcontrib><creatorcontrib>Coughlin, Meghan A.</creatorcontrib><creatorcontrib>Menzel-Smith, Julia</creatorcontrib><creatorcontrib>Najjar, Mary</creatorcontrib><creatorcontrib>Carr, Benjamin D.</creatorcontrib><creatorcontrib>Parmar, Hemant</creatorcontrib><creatorcontrib>Neil, Jeff</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Perez-Torres, Carlos</creatorcontrib><creatorcontrib>Ge, Xia</creatorcontrib><creatorcontrib>Beeman, Scott C.</creatorcontrib><creatorcontrib>Garbow, Joel R.</creatorcontrib><creatorcontrib>Mychaliska, George B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Church, Joseph T.</au><au>Werner, Nicole L.</au><au>Coughlin, Meghan A.</au><au>Menzel-Smith, Julia</au><au>Najjar, Mary</au><au>Carr, Benjamin D.</au><au>Parmar, Hemant</au><au>Neil, Jeff</au><au>Alexopoulos, Dimitrios</au><au>Perez-Torres, Carlos</au><au>Ge, Xia</au><au>Beeman, Scott C.</au><au>Garbow, Joel R.</au><au>Mychaliska, George B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of an artificial placenta on brain development and injury in premature lambs</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>53</volume><issue>6</issue><spage>1234</spage><epage>1239</epage><pages>1234-1239</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>We evaluated whether brain development continues and brain injury is prevented during Artificial Placenta (AP) support utilizing extracorporeal life support (ECLS).
Lambs at EGA 118days (term=145; n=4) were placed on AP support (venovenous ECLS with jugular drainage and umbilical vein reinfusion) for 7days and sacrificed. Early (EGA 118; n=4) and late (EGA 127; n=4) mechanical ventilation (MV) lambs underwent conventional MV for up to 48h and were sacrificed, and early (n=5) and late (n=5) tissue control (TC) lambs were sacrificed at delivery. Brains were harvested, formalin-fixed, rehydrated, and studied by magnetic resonance imaging (MRI). The gyrification index (GI), a measure of cerebral folding complexity, was calculated for each brain. Diffusion-weighted imaging was used to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in multiple structures to assess white matter (WM) integrity.
No intracranial hemorrhage was observed. GI was similar between AP and TC groups. ADC and FA did not differ between AP and late TC groups in any structure. Compared to late MV brains, AP brains demonstrated significantly higher ADC (0.45±0.08 vs. 0.27±0.11, p=0.02) and FA (0.61±0.04 vs. 0.44±0.05; p=0.006) in the cerebral peduncles.
After 7days of AP support, WM integrity is preserved relative to mechanical ventilation.
Research study.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29605267</pmid><doi>10.1016/j.jpedsurg.2018.02.091</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pediatric surgery, 2018-06, Vol.53 (6), p.1234-1239 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anisotropy Artificial Organs Artificial placenta Brain - diagnostic imaging Brain - growth & development Brain development Brain Injuries - diagnostic imaging Brain Injuries - prevention & control Disease Models, Animal Extracorporeal life support Extracorporeal Membrane Oxygenation - methods Female Humans Infant, Premature - physiology Magnetic Resonance Imaging Placenta Pregnancy Prematurity Respiration, Artificial Sheep White matter injury |
| title | Effects of an artificial placenta on brain development and injury in premature lambs |
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