Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase

The ability to incorporate non-canonical amino acids (ncAA) using translation offers researchers the ability to extend the functionality of proteins and peptides for many applications including synthetic biology, biophysical and structural studies, and discovery of novel ligands. Here we describe th...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018, Vol.16 (7), p.1073-1078
Hauptverfasser:	Iqbal, Emil S, Dods, Kara K, Hartman, Matthew C T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Aminoacyl-tRNA ligase Editing Peptides Proteins Translation tRNA Val Valine
Online-Zugang:	Volltext
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