Honeybees show adaptive reactions to ethanol exposure
The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis th...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2018-06, Vol.8 (1), p.8707-6, Article 8707 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6 |
|---|---|
| container_issue | 1 |
| container_start_page | 8707 |
| container_title | Scientific reports |
| container_volume | 8 |
| creator | Miler, Krzysztof Kuszewska, Karolina Privalova, Valeriya Woyciechowski, Michal |
| description | The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis that the response to ethanol (in terms of motor impairment) is lower in bees that have previously experienced intoxication than in bees encountering ethanol for the first time, indicating that the chronic tolerance effect occurs in honeybees. Furthermore, we investigated the basis of this effect and found that it likely results from conditioned compensatory responses to cues associated with ethanol delivery. Our findings significantly improve our understanding of the suitability of honeybees as models for alcoholism-related research and underline the first and foremost function of all conditioned reactions – their adaptive value. |
| doi_str_mv | 10.1038/s41598-018-27117-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5992188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2052808537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-f239a9b664cb6c4894e9afee619454a1665b7979efda20a560e213ca462037463</originalsourceid><addsrcrecordid>eNp9kb1OwzAUhS0EolXpCzCgSCwsAf8nXpBQBRSpEgvMlpPetKnSuNhJoW-PS0opDNiDLd3P5_rcg9A5wdcEs_TGcyJUGmOSxjQhJInlEepTzEVMGaXHB_ceGnq_wGEJqjhRp6hHVZrisPtIjG0NmwzAR35u3yMzNaumXEPkwORNaWsfNTaCZm5qW0XwsbK-dXCGTgpTeRjuzgF6fbh_GY3jyfPj0-huEueCkCYuKFNGZVLyPJM5TxUHZQoASRQX3BApRZaoREExNRQbITFQwnLDJcUs4ZIN0G2nu2qzJUxzqBtnKr1y5dK4jbam1L8rdTnXM7vWQilK0jQIXO0EnH1rwTd6WfocqsrUYFuvaZhJmINgSUAv_6AL27o62NtSRHImMQ4U7ajcWe8dFPvPEKy3weguGB2C0V_B6K2Ni0Mb-yffMQSAdYAPpXoG7qf3P7KfXU2YLQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2051643600</pqid></control><display><type>article</type><title>Honeybees show adaptive reactions to ethanol exposure</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Miler, Krzysztof ; Kuszewska, Karolina ; Privalova, Valeriya ; Woyciechowski, Michal</creator><creatorcontrib>Miler, Krzysztof ; Kuszewska, Karolina ; Privalova, Valeriya ; Woyciechowski, Michal</creatorcontrib><description>The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis that the response to ethanol (in terms of motor impairment) is lower in bees that have previously experienced intoxication than in bees encountering ethanol for the first time, indicating that the chronic tolerance effect occurs in honeybees. Furthermore, we investigated the basis of this effect and found that it likely results from conditioned compensatory responses to cues associated with ethanol delivery. Our findings significantly improve our understanding of the suitability of honeybees as models for alcoholism-related research and underline the first and foremost function of all conditioned reactions – their adaptive value.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-27117-6</identifier><identifier>PMID: 29880808</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/158/856 ; 631/378/1595/1395 ; 631/601/18 ; Alcohol ; Alcoholism ; Apis mellifera ; Drug abuse ; Ethanol ; Humanities and Social Sciences ; Intoxication ; multidisciplinary ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2018-06, Vol.8 (1), p.8707-6, Article 8707</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-f239a9b664cb6c4894e9afee619454a1665b7979efda20a560e213ca462037463</citedby><cites>FETCH-LOGICAL-c511t-f239a9b664cb6c4894e9afee619454a1665b7979efda20a560e213ca462037463</cites><orcidid>0000-0001-7684-0629</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992188/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992188/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29880808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miler, Krzysztof</creatorcontrib><creatorcontrib>Kuszewska, Karolina</creatorcontrib><creatorcontrib>Privalova, Valeriya</creatorcontrib><creatorcontrib>Woyciechowski, Michal</creatorcontrib><title>Honeybees show adaptive reactions to ethanol exposure</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis that the response to ethanol (in terms of motor impairment) is lower in bees that have previously experienced intoxication than in bees encountering ethanol for the first time, indicating that the chronic tolerance effect occurs in honeybees. Furthermore, we investigated the basis of this effect and found that it likely results from conditioned compensatory responses to cues associated with ethanol delivery. Our findings significantly improve our understanding of the suitability of honeybees as models for alcoholism-related research and underline the first and foremost function of all conditioned reactions – their adaptive value.</description><subject>631/158/856</subject><subject>631/378/1595/1395</subject><subject>631/601/18</subject><subject>Alcohol</subject><subject>Alcoholism</subject><subject>Apis mellifera</subject><subject>Drug abuse</subject><subject>Ethanol</subject><subject>Humanities and Social Sciences</subject><subject>Intoxication</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kb1OwzAUhS0EolXpCzCgSCwsAf8nXpBQBRSpEgvMlpPetKnSuNhJoW-PS0opDNiDLd3P5_rcg9A5wdcEs_TGcyJUGmOSxjQhJInlEepTzEVMGaXHB_ceGnq_wGEJqjhRp6hHVZrisPtIjG0NmwzAR35u3yMzNaumXEPkwORNaWsfNTaCZm5qW0XwsbK-dXCGTgpTeRjuzgF6fbh_GY3jyfPj0-huEueCkCYuKFNGZVLyPJM5TxUHZQoASRQX3BApRZaoREExNRQbITFQwnLDJcUs4ZIN0G2nu2qzJUxzqBtnKr1y5dK4jbam1L8rdTnXM7vWQilK0jQIXO0EnH1rwTd6WfocqsrUYFuvaZhJmINgSUAv_6AL27o62NtSRHImMQ4U7ajcWe8dFPvPEKy3weguGB2C0V_B6K2Ni0Mb-yffMQSAdYAPpXoG7qf3P7KfXU2YLQ</recordid><startdate>20180607</startdate><enddate>20180607</enddate><creator>Miler, Krzysztof</creator><creator>Kuszewska, Karolina</creator><creator>Privalova, Valeriya</creator><creator>Woyciechowski, Michal</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7684-0629</orcidid></search><sort><creationdate>20180607</creationdate><title>Honeybees show adaptive reactions to ethanol exposure</title><author>Miler, Krzysztof ; Kuszewska, Karolina ; Privalova, Valeriya ; Woyciechowski, Michal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-f239a9b664cb6c4894e9afee619454a1665b7979efda20a560e213ca462037463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>631/158/856</topic><topic>631/378/1595/1395</topic><topic>631/601/18</topic><topic>Alcohol</topic><topic>Alcoholism</topic><topic>Apis mellifera</topic><topic>Drug abuse</topic><topic>Ethanol</topic><topic>Humanities and Social Sciences</topic><topic>Intoxication</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miler, Krzysztof</creatorcontrib><creatorcontrib>Kuszewska, Karolina</creatorcontrib><creatorcontrib>Privalova, Valeriya</creatorcontrib><creatorcontrib>Woyciechowski, Michal</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miler, Krzysztof</au><au>Kuszewska, Karolina</au><au>Privalova, Valeriya</au><au>Woyciechowski, Michal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Honeybees show adaptive reactions to ethanol exposure</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-06-07</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>8707</spage><epage>6</epage><pages>8707-6</pages><artnum>8707</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis that the response to ethanol (in terms of motor impairment) is lower in bees that have previously experienced intoxication than in bees encountering ethanol for the first time, indicating that the chronic tolerance effect occurs in honeybees. Furthermore, we investigated the basis of this effect and found that it likely results from conditioned compensatory responses to cues associated with ethanol delivery. Our findings significantly improve our understanding of the suitability of honeybees as models for alcoholism-related research and underline the first and foremost function of all conditioned reactions – their adaptive value.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29880808</pmid><doi>10.1038/s41598-018-27117-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7684-0629</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2018-06, Vol.8 (1), p.8707-6, Article 8707 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5992188 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Free; PubMed Central; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 631/158/856 631/378/1595/1395 631/601/18 Alcohol Alcoholism Apis mellifera Drug abuse Ethanol Humanities and Social Sciences Intoxication multidisciplinary Science Science (multidisciplinary) |
| title | Honeybees show adaptive reactions to ethanol exposure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A08%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Honeybees%20show%20adaptive%20reactions%20to%20ethanol%20exposure&rft.jtitle=Scientific%20reports&rft.au=Miler,%20Krzysztof&rft.date=2018-06-07&rft.volume=8&rft.issue=1&rft.spage=8707&rft.epage=6&rft.pages=8707-6&rft.artnum=8707&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-018-27117-6&rft_dat=%3Cproquest_pubme%3E2052808537%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2051643600&rft_id=info:pmid/29880808&rfr_iscdi=true |