The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex is necessary to silence retrotransposons and whether it collaborates with T...

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Veröffentlicht in:	Genome research 2018-06, Vol.28 (6), p.836-845
Hauptverfasser:	Robbez-Masson, Luisa, Tie, Christopher H C, Conde, Lucia, Tunbak, Hale, Husovsky, Connor, Tchasovnikarova, Iva A, Timms, Richard T, Herrero, Javier, Lehner, Paul J, Rowe, Helen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Endogenous Retroviruses - genetics Gene expression Genome, Human Genomes Heterochromatin Heterochromatin - genetics Humans Long Interspersed Nucleotide Elements - genetics Mice Nuclear Proteins - genetics Pluripotency Promoter Regions, Genetic Retroelements - genetics Stem cell transplantation Stem cells Tripartite Motif-Containing Protein 28 - genetics
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