The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF...

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Veröffentlicht in:	Cell metabolism 2018-06, Vol.27 (6), p.1338-1347.e4
Hauptverfasser:	Song, Parkyong, Zechner, Christoph, Hernandez, Genaro, Cánovas, José, Xie, Yang, Sondhi, Varun, Wagner, Martin, Stadlbauer, Vanessa, Horvath, Angela, Leber, Bettina, Hu, Ming Chang, Moe, Orson W., Mangelsdorf, David J., Kliewer, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adult alcohol Alcohol Drinking - adverse effects Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Diet, Ketogenic - adverse effects Drinking - drug effects Drinking - physiology Female FGF21 Fibroblast Growth Factors - administration & dosage Fibroblast Growth Factors - genetics Fibroblast Growth Factors - pharmacology Fibroblast Growth Factors - physiology Healthy Volunteers Humans hypothalamus Hypothalamus - metabolism ketogenic diet Male Mice Mice, Inbred C57BL Mice, Knockout neurons Repressor Proteins - metabolism Signal Transduction water drinking β-adrenergic signaling β-klotho
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