The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol
Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF...
Gespeichert in:
| Veröffentlicht in: | Cell metabolism 2018-06, Vol.27 (6), p.1338-1347.e4 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1347.e4 |
|---|---|
| container_issue | 6 |
| container_start_page | 1338 |
| container_title | Cell metabolism |
| container_volume | 27 |
| creator | Song, Parkyong Zechner, Christoph Hernandez, Genaro Cánovas, José Xie, Yang Sondhi, Varun Wagner, Martin Stadlbauer, Vanessa Horvath, Angela Leber, Bettina Hu, Ming Chang Moe, Orson W. Mangelsdorf, David J. Kliewer, Steven A. |
| description | Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr. Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet. The effect of FGF21 on drinking is mediated in part by SIM1-positive neurons of the hypothalamus and is inhibited by β-adrenergic receptor antagonists. Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.
[Display omitted]
•FGF21 stimulates water drinking behavior in response to alcohol and a ketogenic diet•SIM1 neurons in the hypothalamus contribute to FGF21’s effect on drinking behavior•The FGF21-induced thirst response depends on β-adrenergic signaling
Song et al. show that the metabolic hormone FGF21 is involved in water drinking in response to metabolic stresses, such as alcohol intake and ketogenic diets, which can cause dehydration. The effect of FGF21 on water balance is mediated by a hypothalamic circuit that is dependent on β-adrenergic signaling. |
| doi_str_mv | 10.1016/j.cmet.2018.04.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5990458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550413118302420</els_id><sourcerecordid>2025801898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-ae831e33fae190fa76c18af290d65dd10c55e52b796506302fe6fc00882946fa3</originalsourceid><addsrcrecordid>eNp9kU1rHDEMhk1oaD6aP5BD8bGXmcj2eHYMIRCSblIaKLQJORrHo9n1dsbe2t5A_329bBraSy6SQK9eCT2EnDKoGbD2bFXbCXPNgXU1NDUA2yOHTAlezRoO70otJVQNE-yAHKW0AhCtUOI9OeCqlTPg6pA83C-R3oY4BY90fjPnjP7IbtqMJmOijyVGeh2d_-n8gjpPv2NaB5-Q5kC_Yg4L9M7Sa4eZGt_Ty9GGZRg_kP3BjAlPXvIxeZh_vr-6re6-3Xy5uryrrOQsVwY7wVCIwSBTMJhZa1lnBq6gb2XfM7BSouRPs3IutAL4gO1gAbqOq6YdjDgmFzvf9eZpwt6iz9GMeh3dZOJvHYzT_3e8W-pFeNZSKWhkVww-vRjE8GuDKevJJYvjaDyGTdIcuOzKf9VWyndSG0NKEYfXNQz0lode6S0PveWhodGFRxn6-O-BryN_ARTB-U6A5U3PDqNO1qG32LuINus-uLf8_wAKJJwC</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025801898</pqid></control><display><type>article</type><title>The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Song, Parkyong ; Zechner, Christoph ; Hernandez, Genaro ; Cánovas, José ; Xie, Yang ; Sondhi, Varun ; Wagner, Martin ; Stadlbauer, Vanessa ; Horvath, Angela ; Leber, Bettina ; Hu, Ming Chang ; Moe, Orson W. ; Mangelsdorf, David J. ; Kliewer, Steven A.</creator><creatorcontrib>Song, Parkyong ; Zechner, Christoph ; Hernandez, Genaro ; Cánovas, José ; Xie, Yang ; Sondhi, Varun ; Wagner, Martin ; Stadlbauer, Vanessa ; Horvath, Angela ; Leber, Bettina ; Hu, Ming Chang ; Moe, Orson W. ; Mangelsdorf, David J. ; Kliewer, Steven A.</creatorcontrib><description>Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr. Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet. The effect of FGF21 on drinking is mediated in part by SIM1-positive neurons of the hypothalamus and is inhibited by β-adrenergic receptor antagonists. Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.
[Display omitted]
•FGF21 stimulates water drinking behavior in response to alcohol and a ketogenic diet•SIM1 neurons in the hypothalamus contribute to FGF21’s effect on drinking behavior•The FGF21-induced thirst response depends on β-adrenergic signaling
Song et al. show that the metabolic hormone FGF21 is involved in water drinking in response to metabolic stresses, such as alcohol intake and ketogenic diets, which can cause dehydration. The effect of FGF21 on water balance is mediated by a hypothalamic circuit that is dependent on β-adrenergic signaling.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2018.04.001</identifier><identifier>PMID: 29657029</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenergic beta-Antagonists - administration & dosage ; Adult ; alcohol ; Alcohol Drinking - adverse effects ; Animals ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Diet, Ketogenic - adverse effects ; Drinking - drug effects ; Drinking - physiology ; Female ; FGF21 ; Fibroblast Growth Factors - administration & dosage ; Fibroblast Growth Factors - genetics ; Fibroblast Growth Factors - pharmacology ; Fibroblast Growth Factors - physiology ; Healthy Volunteers ; Humans ; hypothalamus ; Hypothalamus - metabolism ; ketogenic diet ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; neurons ; Repressor Proteins - metabolism ; Signal Transduction ; water drinking ; β-adrenergic signaling ; β-klotho</subject><ispartof>Cell metabolism, 2018-06, Vol.27 (6), p.1338-1347.e4</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-ae831e33fae190fa76c18af290d65dd10c55e52b796506302fe6fc00882946fa3</citedby><cites>FETCH-LOGICAL-c521t-ae831e33fae190fa76c18af290d65dd10c55e52b796506302fe6fc00882946fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2018.04.001$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29657029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Parkyong</creatorcontrib><creatorcontrib>Zechner, Christoph</creatorcontrib><creatorcontrib>Hernandez, Genaro</creatorcontrib><creatorcontrib>Cánovas, José</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Sondhi, Varun</creatorcontrib><creatorcontrib>Wagner, Martin</creatorcontrib><creatorcontrib>Stadlbauer, Vanessa</creatorcontrib><creatorcontrib>Horvath, Angela</creatorcontrib><creatorcontrib>Leber, Bettina</creatorcontrib><creatorcontrib>Hu, Ming Chang</creatorcontrib><creatorcontrib>Moe, Orson W.</creatorcontrib><creatorcontrib>Mangelsdorf, David J.</creatorcontrib><creatorcontrib>Kliewer, Steven A.</creatorcontrib><title>The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr. Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet. The effect of FGF21 on drinking is mediated in part by SIM1-positive neurons of the hypothalamus and is inhibited by β-adrenergic receptor antagonists. Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.
[Display omitted]
•FGF21 stimulates water drinking behavior in response to alcohol and a ketogenic diet•SIM1 neurons in the hypothalamus contribute to FGF21’s effect on drinking behavior•The FGF21-induced thirst response depends on β-adrenergic signaling
Song et al. show that the metabolic hormone FGF21 is involved in water drinking in response to metabolic stresses, such as alcohol intake and ketogenic diets, which can cause dehydration. The effect of FGF21 on water balance is mediated by a hypothalamic circuit that is dependent on β-adrenergic signaling.</description><subject>Adrenergic beta-Antagonists - administration & dosage</subject><subject>Adult</subject><subject>alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Diet, Ketogenic - adverse effects</subject><subject>Drinking - drug effects</subject><subject>Drinking - physiology</subject><subject>Female</subject><subject>FGF21</subject><subject>Fibroblast Growth Factors - administration & dosage</subject><subject>Fibroblast Growth Factors - genetics</subject><subject>Fibroblast Growth Factors - pharmacology</subject><subject>Fibroblast Growth Factors - physiology</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>ketogenic diet</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>neurons</subject><subject>Repressor Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>water drinking</subject><subject>β-adrenergic signaling</subject><subject>β-klotho</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rHDEMhk1oaD6aP5BD8bGXmcj2eHYMIRCSblIaKLQJORrHo9n1dsbe2t5A_329bBraSy6SQK9eCT2EnDKoGbD2bFXbCXPNgXU1NDUA2yOHTAlezRoO70otJVQNE-yAHKW0AhCtUOI9OeCqlTPg6pA83C-R3oY4BY90fjPnjP7IbtqMJmOijyVGeh2d_-n8gjpPv2NaB5-Q5kC_Yg4L9M7Sa4eZGt_Ty9GGZRg_kP3BjAlPXvIxeZh_vr-6re6-3Xy5uryrrOQsVwY7wVCIwSBTMJhZa1lnBq6gb2XfM7BSouRPs3IutAL4gO1gAbqOq6YdjDgmFzvf9eZpwt6iz9GMeh3dZOJvHYzT_3e8W-pFeNZSKWhkVww-vRjE8GuDKevJJYvjaDyGTdIcuOzKf9VWyndSG0NKEYfXNQz0lode6S0PveWhodGFRxn6-O-BryN_ARTB-U6A5U3PDqNO1qG32LuINus-uLf8_wAKJJwC</recordid><startdate>20180605</startdate><enddate>20180605</enddate><creator>Song, Parkyong</creator><creator>Zechner, Christoph</creator><creator>Hernandez, Genaro</creator><creator>Cánovas, José</creator><creator>Xie, Yang</creator><creator>Sondhi, Varun</creator><creator>Wagner, Martin</creator><creator>Stadlbauer, Vanessa</creator><creator>Horvath, Angela</creator><creator>Leber, Bettina</creator><creator>Hu, Ming Chang</creator><creator>Moe, Orson W.</creator><creator>Mangelsdorf, David J.</creator><creator>Kliewer, Steven A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180605</creationdate><title>The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol</title><author>Song, Parkyong ; Zechner, Christoph ; Hernandez, Genaro ; Cánovas, José ; Xie, Yang ; Sondhi, Varun ; Wagner, Martin ; Stadlbauer, Vanessa ; Horvath, Angela ; Leber, Bettina ; Hu, Ming Chang ; Moe, Orson W. ; Mangelsdorf, David J. ; Kliewer, Steven A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-ae831e33fae190fa76c18af290d65dd10c55e52b796506302fe6fc00882946fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adrenergic beta-Antagonists - administration & dosage</topic><topic>Adult</topic><topic>alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Diet, Ketogenic - adverse effects</topic><topic>Drinking - drug effects</topic><topic>Drinking - physiology</topic><topic>Female</topic><topic>FGF21</topic><topic>Fibroblast Growth Factors - administration & dosage</topic><topic>Fibroblast Growth Factors - genetics</topic><topic>Fibroblast Growth Factors - pharmacology</topic><topic>Fibroblast Growth Factors - physiology</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>ketogenic diet</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>neurons</topic><topic>Repressor Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>water drinking</topic><topic>β-adrenergic signaling</topic><topic>β-klotho</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Parkyong</creatorcontrib><creatorcontrib>Zechner, Christoph</creatorcontrib><creatorcontrib>Hernandez, Genaro</creatorcontrib><creatorcontrib>Cánovas, José</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Sondhi, Varun</creatorcontrib><creatorcontrib>Wagner, Martin</creatorcontrib><creatorcontrib>Stadlbauer, Vanessa</creatorcontrib><creatorcontrib>Horvath, Angela</creatorcontrib><creatorcontrib>Leber, Bettina</creatorcontrib><creatorcontrib>Hu, Ming Chang</creatorcontrib><creatorcontrib>Moe, Orson W.</creatorcontrib><creatorcontrib>Mangelsdorf, David J.</creatorcontrib><creatorcontrib>Kliewer, Steven A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Parkyong</au><au>Zechner, Christoph</au><au>Hernandez, Genaro</au><au>Cánovas, José</au><au>Xie, Yang</au><au>Sondhi, Varun</au><au>Wagner, Martin</au><au>Stadlbauer, Vanessa</au><au>Horvath, Angela</au><au>Leber, Bettina</au><au>Hu, Ming Chang</au><au>Moe, Orson W.</au><au>Mangelsdorf, David J.</au><au>Kliewer, Steven A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2018-06-05</date><risdate>2018</risdate><volume>27</volume><issue>6</issue><spage>1338</spage><epage>1347.e4</epage><pages>1338-1347.e4</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr. Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet. The effect of FGF21 on drinking is mediated in part by SIM1-positive neurons of the hypothalamus and is inhibited by β-adrenergic receptor antagonists. Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.
[Display omitted]
•FGF21 stimulates water drinking behavior in response to alcohol and a ketogenic diet•SIM1 neurons in the hypothalamus contribute to FGF21’s effect on drinking behavior•The FGF21-induced thirst response depends on β-adrenergic signaling
Song et al. show that the metabolic hormone FGF21 is involved in water drinking in response to metabolic stresses, such as alcohol intake and ketogenic diets, which can cause dehydration. The effect of FGF21 on water balance is mediated by a hypothalamic circuit that is dependent on β-adrenergic signaling.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29657029</pmid><doi>10.1016/j.cmet.2018.04.001</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-4131 |
| ispartof | Cell metabolism, 2018-06, Vol.27 (6), p.1338-1347.e4 |
| issn | 1550-4131 1932-7420 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5990458 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-Antagonists - administration & dosage Adult alcohol Alcohol Drinking - adverse effects Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Diet, Ketogenic - adverse effects Drinking - drug effects Drinking - physiology Female FGF21 Fibroblast Growth Factors - administration & dosage Fibroblast Growth Factors - genetics Fibroblast Growth Factors - pharmacology Fibroblast Growth Factors - physiology Healthy Volunteers Humans hypothalamus Hypothalamus - metabolism ketogenic diet Male Mice Mice, Inbred C57BL Mice, Knockout neurons Repressor Proteins - metabolism Signal Transduction water drinking β-adrenergic signaling β-klotho |
| title | The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T21%3A43%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Hormone%20FGF21%20Stimulates%20Water%20Drinking%20in%20Response%20to%20Ketogenic%20Diet%20and%20Alcohol&rft.jtitle=Cell%20metabolism&rft.au=Song,%20Parkyong&rft.date=2018-06-05&rft.volume=27&rft.issue=6&rft.spage=1338&rft.epage=1347.e4&rft.pages=1338-1347.e4&rft.issn=1550-4131&rft.eissn=1932-7420&rft_id=info:doi/10.1016/j.cmet.2018.04.001&rft_dat=%3Cproquest_pubme%3E2025801898%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2025801898&rft_id=info:pmid/29657029&rft_els_id=S1550413118302420&rfr_iscdi=true |