Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells

Adult neural stem cells (NSCs) play important roles in learning and memory and are negatively impacted by neurological disease. It is known that biochemical and genetic factors regulate self‐renewal and differentiation, and it has recently been suggested that mechanical and solid‐state cues, such as...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2011-11, Vol.29 (11), p.1886-1897
Hauptverfasser:	Keung, Albert J., de Juan‐Pardo, Elena M., Schaffer, David V., Kumar, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose stem cells Animals Apoptosis - genetics Apoptosis - physiology cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Differentiation - genetics Cell Differentiation - physiology Cell Proliferation Cells, Cultured Cellular mechanotransduction Elastic modulus Extracellular matrix Extracellular Matrix - metabolism Female Fluorescent Antibody Technique Mechanotransduction, Cellular - genetics Mechanotransduction, Cellular - physiology Microscopy, Atomic Force Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis - genetics Neurogenesis - physiology Rats Rats, Inbred F344 rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism Rho GTP‐binding proteins rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism
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