Lycium barbarum polysaccharide encapsulated Poly lactic-co-glycolic acid Nanofibers: cost effective herbal medicine for potential application in peripheral nerve tissue engineering
Nerve regeneration is a serious clinical challenge following peripheral nerve injury. Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-...
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| Veröffentlicht in: | Scientific reports 2018-06, Vol.8 (1), p.8669-14, Article 8669 |
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| description | Nerve regeneration is a serious clinical challenge following peripheral nerve injury. Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning. Alamar blue assays were performed to investigate the proliferation of both PC12 and Schwann cells cultured on the scaffolds. The neuronal differentiation of PC12 cells was evaluated by NF200 expression with immunostaining and morphology changes observed by SEM. The results indicated that the released LBP dramatically enhanced both proliferation and neuronal differentiation of PC12 cells induced by NGF. Additionally, the promotion of Schwann cells myelination and neurite outgrowth of DRG neurons were also observed on LBP loaded scaffolds by LSCM with immunostaining. In summary, LBP, as a drug with neuroprotection, encapsulated into electrospun nanofibers could be a potential candidate as tissue engineered scaffold for peripheral nerve regeneration. |
| doi_str_mv | 10.1038/s41598-018-26837-z |
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Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning. Alamar blue assays were performed to investigate the proliferation of both PC12 and Schwann cells cultured on the scaffolds. The neuronal differentiation of PC12 cells was evaluated by NF200 expression with immunostaining and morphology changes observed by SEM. The results indicated that the released LBP dramatically enhanced both proliferation and neuronal differentiation of PC12 cells induced by NGF. Additionally, the promotion of Schwann cells myelination and neurite outgrowth of DRG neurons were also observed on LBP loaded scaffolds by LSCM with immunostaining. In summary, LBP, as a drug with neuroprotection, encapsulated into electrospun nanofibers could be a potential candidate as tissue engineered scaffold for peripheral nerve regeneration.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-26837-z</identifier><identifier>PMID: 29875468</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/107 ; 140/125 ; 639/301/54/2295 ; 692/617/375/430 ; 82/1 ; 82/80 ; Animals ; Axonogenesis ; Cell proliferation ; Cell Proliferation - drug effects ; Cells, Cultured ; Drug Carriers - chemistry ; Drug delivery ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Glycolic acid ; Herbal medicine ; Humanities and Social Sciences ; Lycium barbarum ; multidisciplinary ; Myelination ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Nerve growth factor ; Nerve Regeneration - drug effects ; Nervous tissues ; Neurogenesis - drug effects ; Neuronal Outgrowth - drug effects ; Neurons - cytology ; Neurons - drug effects ; Neuroprotection ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - pharmacology ; PC12 Cells ; Pheochromocytoma cells ; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry ; Polysaccharides ; Rats ; Regeneration ; Schwann cells ; Schwann Cells - cytology ; Schwann Cells - drug effects ; Science ; Science (multidisciplinary) ; Tissue Engineering ; Tissue Scaffolds - chemistry</subject><ispartof>Scientific reports, 2018-06, Vol.8 (1), p.8669-14, Article 8669</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning. Alamar blue assays were performed to investigate the proliferation of both PC12 and Schwann cells cultured on the scaffolds. The neuronal differentiation of PC12 cells was evaluated by NF200 expression with immunostaining and morphology changes observed by SEM. The results indicated that the released LBP dramatically enhanced both proliferation and neuronal differentiation of PC12 cells induced by NGF. Additionally, the promotion of Schwann cells myelination and neurite outgrowth of DRG neurons were also observed on LBP loaded scaffolds by LSCM with immunostaining. In summary, LBP, as a drug with neuroprotection, encapsulated into electrospun nanofibers could be a potential candidate as tissue engineered scaffold for peripheral nerve regeneration.</description><subject>13/1</subject><subject>13/107</subject><subject>140/125</subject><subject>639/301/54/2295</subject><subject>692/617/375/430</subject><subject>82/1</subject><subject>82/80</subject><subject>Animals</subject><subject>Axonogenesis</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Glycolic acid</subject><subject>Herbal medicine</subject><subject>Humanities and Social Sciences</subject><subject>Lycium barbarum</subject><subject>multidisciplinary</subject><subject>Myelination</subject><subject>Nanofibers - 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Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning. Alamar blue assays were performed to investigate the proliferation of both PC12 and Schwann cells cultured on the scaffolds. The neuronal differentiation of PC12 cells was evaluated by NF200 expression with immunostaining and morphology changes observed by SEM. The results indicated that the released LBP dramatically enhanced both proliferation and neuronal differentiation of PC12 cells induced by NGF. Additionally, the promotion of Schwann cells myelination and neurite outgrowth of DRG neurons were also observed on LBP loaded scaffolds by LSCM with immunostaining. In summary, LBP, as a drug with neuroprotection, encapsulated into electrospun nanofibers could be a potential candidate as tissue engineered scaffold for peripheral nerve regeneration.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29875468</pmid><doi>10.1038/s41598-018-26837-z</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 13/107 140/125 639/301/54/2295 692/617/375/430 82/1 82/80 Animals Axonogenesis Cell proliferation Cell Proliferation - drug effects Cells, Cultured Drug Carriers - chemistry Drug delivery Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Glycolic acid Herbal medicine Humanities and Social Sciences Lycium barbarum multidisciplinary Myelination Nanofibers - chemistry Nanofibers - ultrastructure Nerve growth factor Nerve Regeneration - drug effects Nervous tissues Neurogenesis - drug effects Neuronal Outgrowth - drug effects Neurons - cytology Neurons - drug effects Neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology PC12 Cells Pheochromocytoma cells Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polysaccharides Rats Regeneration Schwann cells Schwann Cells - cytology Schwann Cells - drug effects Science Science (multidisciplinary) Tissue Engineering Tissue Scaffolds - chemistry |
| title | Lycium barbarum polysaccharide encapsulated Poly lactic-co-glycolic acid Nanofibers: cost effective herbal medicine for potential application in peripheral nerve tissue engineering |
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