Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males

A hallmark of naive pluripotency is the presence of two active X chromosomes in females. It is not clear whether prevention of X chromosome inactivation (XCI) is mediated by gene networks that preserve the naive state. Here, we show that robust naive pluripotent stem cell (nPSC) self-renewal repress...

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Veröffentlicht in:	Cell stem cell 2018-06, Vol.22 (6), p.919-928.e6
Hauptverfasser:	Sousa, Elsa J., Stuart, Hannah T., Bates, Lawrence E., Ghorbani, Mohammadmersad, Nichols, Jennifer, Dietmann, Sabine, Silva, José C.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured Female Male Mice Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism RNA, Long Noncoding - genetics X Chromosome - genetics X Chromosome Inactivation - genetics
Online-Zugang:	Volltext
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