Negative modulation of spinal κ-opioid receptor-mediated antinociception by the µ-opioid receptor at selective doses of (−)-pentazocine

The mixed-action κ-opioid receptor (KOR) agonist, pentazocine, binds to both KOR and the µ-opioid receptor (MOR). Racemic (±)-pentazocine and (−)-pentazocine, each administered systemically, have been shown to produce antinociception in various animal models. In contrast, racemic (±)-pentazocine fai...

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Veröffentlicht in:	Neuroreport 2018-07, Vol.29 (10), p.852-855
Hauptverfasser:	Robinson, Douglas L, Nag, Subodh, Mokha, Sukhbir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Integrative Systems Male Morphine - pharmacology Pain Measurement - drug effects Pentazocine - pharmacology Rats, Sprague-Dawley Receptors, Opioid, kappa - drug effects Spinal Cord - drug effects Spinal Cord - metabolism
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