Src family kinases (SFKs) and cell polarity in the testis
Non-receptor Src family kinases (SFKs), most notably c-Src and c-Yes, are recently shown to be expressed by Sertoli and/or germ cells in adult rat testes. Studies have shown that SFKs are involved in modulating the cell cytoskeletal function, and involved in endocytic vesicle-mediated protein endocy...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2018-09, Vol.81, p.46-53 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Xiao, Xiang Ni, Ya Yu, Chenhuan Li, Linxi Mao, Baiping Yang, Yue Zheng, Dongwang Silvestrini, Bruno Cheng, C. Yan |
| description | Non-receptor Src family kinases (SFKs), most notably c-Src and c-Yes, are recently shown to be expressed by Sertoli and/or germ cells in adult rat testes. Studies have shown that SFKs are involved in modulating the cell cytoskeletal function, and involved in endocytic vesicle-mediated protein endocytosis, transcytosis and/or recycling as well as intracellular protein degradation events. Furthermore, a knockdown to SFKs, in particular c-Yes, has shown to induce defects in spermatid polarity. These findings, coupled with emerging evidence in the field, thus prompt us to critically evaluate them to put forth a developing concept regarding the role of SFKs and cell polarity, which will become a basis to design experiments for future investigations. |
| doi_str_mv | 10.1016/j.semcdb.2017.11.024 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Seminars in cell & developmental biology, 2018-09, Vol.81, p.46-53 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals c-Src c-Yes Cell polarity Cell Polarity - physiology Cytoskeleton - metabolism Humans Male Sertoli cells Sertoli Cells - cytology Sertoli Cells - metabolism Spermatids Spermatids - cytology Spermatids - physiology Spermatogenesis Src family kinases src-Family Kinases - genetics src-Family Kinases - metabolism Testis Testis - cytology Testis - metabolism |
| title | Src family kinases (SFKs) and cell polarity in the testis |
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