Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

A defining feature of resident gut macrophages is their high replenishment rate from blood monocytes attributed to tonic commensal stimulation of this site. In contrast, almost all other tissues contain locally maintained macrophage populations, which coexist with monocyte-replenished cells at homeo...

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Veröffentlicht in:	The Journal of experimental medicine 2018-06, Vol.215 (6), p.1507-1518
Hauptverfasser:	Shaw, Tovah N, Houston, Stephanie A, Wemyss, Kelly, Bridgeman, Hayley M, Barbera, Thomas A, Zangerle-Murray, Tamsin, Strangward, Patrick, Ridley, Amanda J L, Wang, Ping, Tamoutounour, Samira, Allen, Judith E, Konkel, Joanne E, Grainger, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Blood CD4 antigen CD4 Antigens - metabolism Digestive system Gastrointestinal tract Homeostasis Intestine Intestines - cytology Intestines - microbiology Macrophages Macrophages - metabolism Membrane Proteins - metabolism Mice, Inbred C57BL Microbiomes Microbiota Monocytes Monocytes - metabolism Ontogeny Phenotype Populations Receptors, CCR2 - metabolism Replenishment Subpopulations Transcription Transcription, Genetic
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