Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

( ) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that mutations might confer an alteration of function. In this study, we identify that physiological e...

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