Mechanotransduction via the LINC complex regulates DNA replication in myonuclei

Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear. We found that deleting components of the linker of nucleoskeleton and cytoskeleton (LINC) complex in larval muscles abolishes the controlled a...

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Veröffentlicht in:	The Journal of cell biology 2018-06, Vol.217 (6), p.2005-2018
Hauptverfasser:	Wang, Shuoshuo, Stoops, Elizabeth, Cp, Unnikannan, Markus, Barak, Reuveny, Adriana, Ordan, Elly, Volk, Talila
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-binding protein Cells Chromatin Cytoskeleton Deoxyribonucleic acid DNA DNA biosynthesis DNA-directed RNA polymerase Fruit flies Genomes Mechanical stimuli Mechanotransduction Muscle contraction Muscles Phenotypes Proteins Ribonucleic acid RNA Troponin Troponin C
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